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10.1126/sciadv.abc1564 http://scihub22266oqcxt.onion/10.1126/sciadv.abc1564 32937590!10715714!32937590     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Adv 2020 ; 6 (31): ä Nephropedia Template TP {{tp|p=32937590|t=2020. Acetylated K676 TGFBIp as a severity diagnostic blood biomarker for SARS-CoV-2 pneumonia |pdf=|usr=}}{{32937590}} gab.com Text Acetylated K676 TGFBIp as a severity diagnostic blood biomarker for SARS-CoV-2 pneumonia JO: Sci Adv http://www.kidney.de/pget.php?&tw=1&pmid=32937590 #FOAvip The outbreak of the highly contagious and deadly severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known as coronavirus disease 2019 (COVID-19), has posed a serious threat to public health across the globe, calling for the development of effective diagnostic markers and therapeutics. Here, we report a highly reliable severity diagnostic biomarker, acetylated 676th lysine transforming growth factor-beta-induced protein (TGFBIp K676Ac). TGFBIp K676Ac was consistently elevated in the blood of patients with SARS-CoV-2 pneumonia (n = 113), especially in patients in the intensive care unit (ICU) compared to non-ICU patients. Patients' blood samples showed increased cytokines and lymphopenia, which are exemplary indicators of SARS-CoV-2 pneumonia. Treatment with TGFBIp neutralizing antibodies suppressed the cytokine storm. The increased level of TGFBIp K676Ac in ICU patients suggests the promise of this protein as a reliable severity diagnostic biomarker for severe SARS-CoV-2 disease. Twit Text FOAVip Acetylated K676 TGFBIp as a severity diagnostic blood biomarker for SARS-CoV-2 pneumonia ????Sci Adv http://www.kidney.de/pget.php?&tw=1&pmid=32937590 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32937590 #FOAvip English Wikipedia <ref>{{Cite pmid|32937590}}</ref> Acetylated K676 TGFBIp as a severity diagnostic blood biomarker for SARS-CoV-2 pneumonia #MMPMID32937590 Park HH; Kim HN; Kim H; Yoo Y; Shin H; Choi EY; Bae JS; Lee W Sci Adv 2020[Jul]; 6 (31): ä PMID32937590show ga The outbreak of the highly contagious and deadly severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known as coronavirus disease 2019 (COVID-19), has posed a serious threat to public health across the globe, calling for the development of effective diagnostic markers and therapeutics. Here, we report a highly reliable severity diagnostic biomarker, acetylated 676th lysine transforming growth factor-beta-induced protein (TGFBIp K676Ac). TGFBIp K676Ac was consistently elevated in the blood of patients with SARS-CoV-2 pneumonia (n = 113), especially in patients in the intensive care unit (ICU) compared to non-ICU patients. Patients' blood samples showed increased cytokines and lymphopenia, which are exemplary indicators of SARS-CoV-2 pneumonia. Treatment with TGFBIp neutralizing antibodies suppressed the cytokine storm. The increased level of TGFBIp K676Ac in ICU patients suggests the promise of this protein as a reliable severity diagnostic biomarker for severe SARS-CoV-2 disease. |*Protein Processing, Post-Translational[MESH] |Acetylation[MESH] |Antibodies, Neutralizing/pharmacology[MESH] |Betacoronavirus/immunology/*pathogenicity[MESH] |Biomarkers/blood[MESH] |COVID-19[MESH] |Case-Control Studies[MESH] |Coronavirus Infections/blood/*diagnosis/immunology/pathology[MESH] |Cytokine Release Syndrome/blood/*diagnosis/immunology/pathology[MESH] |Extracellular Matrix Proteins/antagonists & inhibitors/genetics/*immunology[MESH] |Gene Expression[MESH] |Humans[MESH] |Intensive Care Units[MESH] |Leukocyte Count[MESH] |Leukocytes, Mononuclear/drug effects/*immunology/pathology/virology[MESH] |Lung/blood supply/drug effects/pathology/virology[MESH] |Lysine/metabolism[MESH] |NF-kappa B/genetics/immunology[MESH] |Pandemics[MESH] |Pneumonia, Viral/blood/*diagnosis/immunology/pathology[MESH] |Primary Cell Culture[MESH] |Prognosis[MESH] |Respiratory Insufficiency/blood/*diagnosis/immunology/pathology[MESH] |SARS-CoV-2[MESH] |Severity of Illness Index[MESH]Acetylated K676 TGFBIp as a severity diagnostic blood biomarker for SA(epmc).pdf DeepDyve Pubget Overpricing