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10.1126/sciadv.abb9153 http://scihub22266oqcxt.onion/10.1126/sciadv.abb9153 32937441!7458444!32937441     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32937441&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Adv 2020 ; 6 (27): ä Nephropedia Template TP {{tp|p=32937441|t=2020. Emergence of SARS-CoV-2 through recombination and strong purifying selection |pdf=|usr=}}{{32937441}} gab.com Text Emergence of SARS-CoV-2 through recombination and strong purifying selection JO: Sci Adv http://www.kidney.de/pget.php?&tw=1&pmid=32937441 #FOAvip COVID-19 has become a global pandemic caused by the novel coronavirus SARS-CoV-2. Understanding the origins of SARS-CoV-2 is critical for deterring future zoonosis, discovering new drugs, and developing a vaccine. We show evidence of strong purifying selection around the receptor binding motif (RBM) in the spike and other genes among bat, pangolin, and human coronaviruses, suggesting similar evolutionary constraints in different host species. We also demonstrate that SARS-CoV-2's entire RBM was introduced through recombination with coronaviruses from pangolins, possibly a critical step in the evolution of SARS-CoV-2's ability to infect humans. Similar purifying selection in different host species, together with frequent recombination among coronaviruses, suggests a common evolutionary mechanism that could lead to new emerging human coronaviruses. Twit Text FOAVip Emergence of SARS-CoV-2 through recombination and strong purifying selection ????Sci Adv http://www.kidney.de/pget.php?&tw=1&pmid=32937441 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32937441 #FOAvip English Wikipedia <ref>{{Cite pmid|32937441}}</ref> Emergence of SARS-CoV-2 through recombination and strong purifying selection #MMPMID32937441 Li X; Giorgi EE; Marichannegowda MH; Foley B; Xiao C; Kong XP; Chen Y; Gnanakaran S; Korber B; Gao F Sci Adv 2020[Jul]; 6 (27): ä PMID32937441show ga COVID-19 has become a global pandemic caused by the novel coronavirus SARS-CoV-2. Understanding the origins of SARS-CoV-2 is critical for deterring future zoonosis, discovering new drugs, and developing a vaccine. We show evidence of strong purifying selection around the receptor binding motif (RBM) in the spike and other genes among bat, pangolin, and human coronaviruses, suggesting similar evolutionary constraints in different host species. We also demonstrate that SARS-CoV-2's entire RBM was introduced through recombination with coronaviruses from pangolins, possibly a critical step in the evolution of SARS-CoV-2's ability to infect humans. Similar purifying selection in different host species, together with frequent recombination among coronaviruses, suggests a common evolutionary mechanism that could lead to new emerging human coronaviruses. |*Recombination, Genetic[MESH] |Amino Acid Sequence[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Animals[MESH] |Betacoronavirus/classification/growth & development/*physiology[MESH] |Binding Sites[MESH] |COVID-19[MESH] |Chiroptera/virology[MESH] |Coronavirus Infections/*pathology/virology[MESH] |Evolution, Molecular[MESH] |Genome, Viral[MESH] |Humans[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/chemistry/metabolism[MESH] |Phylogeny[MESH] |Pneumonia, Viral/*pathology/virology[MESH] |Protein Structure, Tertiary[MESH] |SARS-CoV-2[MESH]Emergence of SARS-CoV-2 through recombination and strong purifying sel(epmc).pdf DeepDyve Pubget Overpricing