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10.1371/journal.pone.0238255 http://scihub22266oqcxt.onion/10.1371/journal.pone.0238255 32936832!7494073!32936832     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2020 ; 15 (9): e0238255 Nephropedia Template TP {{tp|p=32936832|t=2020. Most frequent South Asian haplotypes of ACE2 share identity by descent with East Eurasian populations |pdf=|usr=}}{{32936832}} gab.com Text Most frequent South Asian haplotypes of ACE2 share identity by descent with East Eurasian populations JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=32936832 #FOAvip It was shown that the human Angiotensin-converting enzyme 2 (ACE2) is the receptor of recent coronavirus SARS-CoV-2, and variation in this gene may affect the susceptibility of a population. Therefore, we have analysed the sequence data of ACE2 among 393 samples worldwide, focusing on South Asia. Genetically, South Asians are more related to West Eurasian populations rather than to East Eurasians. In the present analyses of ACE2, we observed that the majority of South Asian haplotypes are closer to East Eurasians rather than to West Eurasians. The phylogenetic analysis suggested that the South Asian haplotypes shared with East Eurasians involved two unique event polymorphisms (rs4646120 and rs2285666). In contrast with the European/American populations, both of the SNPs have largely similar frequencies for East Eurasians and South Asians, Therefore, it is likely that among the South Asians, host susceptibility to the novel coronavirus SARS-CoV-2 will be more similar to that of East Eurasians rather than to that of Europeans. Twit Text FOAVip Most frequent South Asian haplotypes of ACE2 share identity by descent with East Eurasian populations ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=32936832 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32936832 #FOAvip English Wikipedia <ref>{{Cite pmid|32936832}}</ref> Most frequent South Asian haplotypes of ACE2 share identity by descent with East Eurasian populations #MMPMID32936832 Srivastava A; Pandey RK; Singh PP; Kumar P; Rasalkar AA; Tamang R; van Driem G; Shrivastava P; Chaubey G PLoS One 2020[]; 15 (9): e0238255 PMID32936832show ga It was shown that the human Angiotensin-converting enzyme 2 (ACE2) is the receptor of recent coronavirus SARS-CoV-2, and variation in this gene may affect the susceptibility of a population. Therefore, we have analysed the sequence data of ACE2 among 393 samples worldwide, focusing on South Asia. Genetically, South Asians are more related to West Eurasian populations rather than to East Eurasians. In the present analyses of ACE2, we observed that the majority of South Asian haplotypes are closer to East Eurasians rather than to West Eurasians. The phylogenetic analysis suggested that the South Asian haplotypes shared with East Eurasians involved two unique event polymorphisms (rs4646120 and rs2285666). In contrast with the European/American populations, both of the SNPs have largely similar frequencies for East Eurasians and South Asians, Therefore, it is likely that among the South Asians, host susceptibility to the novel coronavirus SARS-CoV-2 will be more similar to that of East Eurasians rather than to that of Europeans. |*Polymorphism, Single Nucleotide[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Asia/epidemiology[MESH] |Asian People/*genetics[MESH] |Betacoronavirus/physiology[MESH] |COVID-19[MESH] |Coronavirus Infections/ethnology/*genetics[MESH] |Haplotypes/genetics[MESH] |Human Migration[MESH] |Humans[MESH] |Linkage Disequilibrium[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/*genetics[MESH] |Phylogeny[MESH] |Pneumonia, Viral/ethnology/*genetics[MESH] |Receptors, Virus/*genetics[MESH] |SARS-CoV-2[MESH]Most frequent South Asian haplotypes of ACE2 share identity by descent(epmc).pdf DeepDyve Pubget Overpricing