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10.1002/jmv.26519 http://scihub22266oqcxt.onion/10.1002/jmv.26519 32936471!ä!32936471 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32936471&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Med+Virol 2021 ; 93 (3): 1568-1572 Nephropedia Template TP {{tp|p=32936471|t=2021. Assessing the dilution effect of specimen pooling on the sensitivity of SARS-CoV-2 PCR tests |pdf=|usr=}}{{32936471}} gab.com Text Assessing the dilution effect of specimen pooling on the sensitivity of SARS-CoV-2 PCR tests JO: J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=32936471 #FOAvip The SARS-CoV-2 pandemic has led to an unprecedented demand for diagnostic tests. Many studies have modeled the efficiency gains of specimen pooling, but few have systematically evaluated the dilution effect of pooling on the sensitivity of tests. Using the frequency distribution of cycle threshold (C(t) ) values of our first 838 SARS-CoV-2 positive specimens, we modeled 100 specimens on the same frequency distribution. Given this distribution, we then tested dilutions of 1:5, 1:10, and 1:50 to find the percentage of specimens positive at each C(t) value with each pool size. Using the frequency distribution and the percentage of specimens positive at each C(t) value, we estimate that pools of 5 lead to 93% sensitivity, pools of 10 lead to 91% sensitivity, and pools of 50 lead to 81% sensitivity. Pools of 5 and 10 lead to some specimens with C(t) values of >/=32 becoming negative, while pools of 50 lead to some specimens with C(t) values of >/=28 becoming negative. These sensitivity estimates can inform laboratories seeking to implement pooling approaches as they seek to balance test efficiency with sensitivity. Twit Text FOAVip Assessing the dilution effect of specimen pooling on the sensitivity of SARS-CoV-2 PCR tests ????J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=32936471 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32936471 #FOAvip English Wikipedia <ref>{{Cite pmid|32936471}}</ref> Assessing the dilution effect of specimen pooling on the sensitivity of SARS-CoV-2 PCR tests #MMPMID32936471 Bateman AC; Mueller S; Guenther K; Shult P J Med Virol 2021[Mar]; 93 (3): 1568-1572 PMID32936471show ga The SARS-CoV-2 pandemic has led to an unprecedented demand for diagnostic tests. Many studies have modeled the efficiency gains of specimen pooling, but few have systematically evaluated the dilution effect of pooling on the sensitivity of tests. Using the frequency distribution of cycle threshold (C(t) ) values of our first 838 SARS-CoV-2 positive specimens, we modeled 100 specimens on the same frequency distribution. Given this distribution, we then tested dilutions of 1:5, 1:10, and 1:50 to find the percentage of specimens positive at each C(t) value with each pool size. Using the frequency distribution and the percentage of specimens positive at each C(t) value, we estimate that pools of 5 lead to 93% sensitivity, pools of 10 lead to 91% sensitivity, and pools of 50 lead to 81% sensitivity. Pools of 5 and 10 lead to some specimens with C(t) values of >/=32 becoming negative, while pools of 50 lead to some specimens with C(t) values of >/=28 becoming negative. These sensitivity estimates can inform laboratories seeking to implement pooling approaches as they seek to balance test efficiency with sensitivity. |COVID-19 Testing/*methods[MESH] |COVID-19/*diagnosis/virology[MESH] |Diagnostic Tests, Routine/methods[MESH] |Humans[MESH] |Pandemics/prevention & control[MESH] |Polymerase Chain Reaction/*methods[MESH] |RNA, Viral/genetics[MESH] |SARS-CoV-2/*genetics[MESH] |Sensitivity and Specificity[MESH]Assessing the dilution effect of specimen pooling on the sensitivity o(epmc).pdf DeepDyve Pubget Overpricing