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10.1590/1806-9282.66.8.1116

http://scihub22266oqcxt.onion/10.1590/1806-9282.66.8.1116
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32935807!ä!32935807

suck abstract from ncbi


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pmid32935807      Rev+Assoc+Med+Bras+(1992) 2020 ; 66 (8): 1116-1121
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  • Comparison of saliva and oro-nasopharyngeal swab sample in the molecular diagnosis of COVID-19 #MMPMID32935807
  • Guclu E; Koroglu M; Yurumez Y; Toptan H; Kose E; Guneysu F; Karabay O
  • Rev Assoc Med Bras (1992) 2020[Aug]; 66 (8): 1116-1121 PMID32935807show ga
  • BACKGROUND: Healthcare personnel are at risk of becoming infected while taking upper and/or lower respiratory tract specimens. Therefore, there is a need for sampling methods that do not risk infecting them. In this study, we aimed to compare the saliva and Oro-Nasopharyngeal Swab (ONS) sampling methods. METHODS: Patients were divided into three groups. Group 1 included patients whose diagnosis of COVID-19 was confirmed by polymerase chain reaction (PCR). Group 2 included patients with COVID-19 compatible findings in lung computed tomography (CT), but with a negative PCR. Group 3 included patients who presented to the emergency department with COVID-19 compatible complaints but had normal CT. Saliva and ONS samples were taken on the third day of hospitalization in groups 1 and 2, whereas in group 3, they were taken at the time of admission to the hospital. RESULTS: A total of 64 patients were included in the study. The average age was 51.04 +/- 17.9 years, and 37 (57.8%) were male. SARS-CoV-2 was detected in 27 (42.2%) patients' saliva samples. While the sensitivity and positive predictive value of saliva samples were 85.2%, specificity and negative predictive value were 89.2%. The value of kappa was in substantial agreement (0.744), and it was found statistically significant (<0.001). CONCLUSIONS: Saliva samples can be used instead of ONS samples in detecting SARS-CoV-2. Investigating SARS-CoV-2 with saliva is cheaper, easier for the patient and overall, and, most importantly, it poses much less risk of SARS-CoV-2 contamination to healthcare personnel.
  • |*Betacoronavirus[MESH]
  • |*Coronavirus Infections/diagnosis[MESH]
  • |*Pandemics[MESH]
  • |*Pneumonia, Viral/diagnosis[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Testing[MESH]
  • |Clinical Laboratory Techniques[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Nasopharynx[MESH]
  • |SARS-CoV-2[MESH]


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