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10.7861/clinmed.2020-0424

http://scihub22266oqcxt.onion/10.7861/clinmed.2020-0424
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32934038!7539728!32934038
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suck abstract from ncbi


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pmid32934038      Clin+Med+(Lond) 2020 ; 20 (5): 463-467
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  • C-reactive protein and albumin association with mortality of hospitalised SARS-CoV-2 patients: A tertiary hospital experience #MMPMID32934038
  • Bannaga AS; Tabuso M; Farrugia A; Chandrapalan S; Somal K; Lim VK; Mohamed S; Nia GJ; Mannath J; Wong JL; Noufaily A; Disney BR; Arasaradnam RP
  • Clin Med (Lond) 2020[Sep]; 20 (5): 463-467 PMID32934038show ga
  • OBJECTIVE: The objective was to study hospitalised COVID-19 patients' mortality and intensive care unit (ICU) admission with covariates of interest (age, gender, ethnicity, clinical presentation, comorbidities and admission laboratory findings). METHODS: Logistic regression analyses were performed for patients admitted to University Hospital, University Hospitals Coventry and Warwickshire NHS Trust, between 24 January 2020 - 13 April 2020. RESULTS: There were 321 patients hospitalised. Median age was 73 years and 189 (59%) were male. Ethnicity was divided between Caucasian (77%), and black, Asian, and minority ethnic (BAME) groups (23%). Commonest symptoms were dyspnoea (62.9%), fever (59.1%) and cough (56%). Gastrointestinal symptoms amounted to 11.8%.Forty-four patients (13.7%) received ICU care. ICU male to female ratio was 3:1 (p=0.027; odds ratio (OR) 2.3; 95% confidence interval (CI) 1.1-4.9), BAME (p=0.008; OR 2.5; 95% CI 1.3-4.9), age >65 years (p=0.026; OR 0.28; 95% CI 0.09-0.93), heart disease (p=0.009; OR 0.2; 95% CI 0.1-0.6) and elevated C-reactive protein (CRP; p<0.001; OR 1.004; 95% CI 1.002-1.008) were associated with ICU admission.One-hundred and four patients (32.4%) died. Age >65 years (p=0.011; OR 5; 95% CI 1.6-21.9), neutrophils (p=0.047), neutrophil:lymphocyte ratio (NLR; p=0.028), CRP (p<0.001) and albumin (p=0.002) were associated with mortality. When analysis adjusted for age, CRP (p<0.001; OR 1.006; 95% CI 1.004-1.008) and albumin (p=0.005; OR 0.94; 95% CI 0.90-0.98) remained associated with mortality. CONCLUSIONS: COVID-19 has high mortality. BAME and male patients were associated with ICU admission. High CRP and low albumin (after correcting for age) were associated with mortality.
  • |*Cause of Death[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Albumins/*metabolism[MESH]
  • |C-Reactive Protein/*metabolism[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*blood/*mortality/physiopathology[MESH]
  • |Female[MESH]
  • |Geriatric Assessment[MESH]
  • |Hospital Mortality/*trends[MESH]
  • |Hospitalization/statistics & numerical data[MESH]
  • |Hospitals, University[MESH]
  • |Humans[MESH]
  • |Intensive Care Units/statistics & numerical data[MESH]
  • |Logistic Models[MESH]
  • |Male[MESH]
  • |Odds Ratio[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*blood/*mortality/physiopathology[MESH]
  • |Retrospective Studies[MESH]
  • |Risk Assessment[MESH]
  • |Severity of Illness Index[MESH]
  • |Tertiary Care Centers[MESH]


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