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10.1016/j.chest.2020.09.077

http://scihub22266oqcxt.onion/10.1016/j.chest.2020.09.077
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32931823!7486855!32931823
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suck abstract from ncbi


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pmid32931823      Chest 2021 ; 159 (1): e7-e11
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  • Etoposide as Salvage Therapy for Cytokine Storm Due to Coronavirus Disease 2019 #MMPMID32931823
  • Patel M; Dominguez E; Sacher D; Desai P; Chandar A; Bromberg M; Caricchio R; Criner GJ
  • Chest 2021[Jan]; 159 (1): e7-e11 PMID32931823show ga
  • Coronavirus disease 2019 (COVID-19) has resulted in significant morbidity and mortality because of a lack of effective therapies. Therapeutic strategies under investigation target the overactive cytokine response with anti-cytokine or immunomodulators therapies. We present a unique case of severe cytokine storm resistant to multiple anti-cytokine therapies, but eventually responsive to etoposide. Thus, etoposide may have a role as salvage therapy in treatment of cytokine storm in COVID-19. To our knowledge, this is the first reported case of use of etoposide in COVID-19.
  • |Aged[MESH]
  • |COVID-19/*complications[MESH]
  • |Cytokine Release Syndrome/*drug therapy/*etiology[MESH]
  • |Etoposide/*therapeutic use[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Salvage Therapy/methods[MESH]


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