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10.1016/j.ejphar.2020.173551

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32931783!7832734!32931783
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suck abstract from ncbi


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pmid32931783      Eur+J+Pharmacol 2020 ; 886 (ä): 173551
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  • Curcumin, a traditional spice component, can hold the promise against COVID-19? #MMPMID32931783
  • Soni VK; Mehta A; Ratre YK; Tiwari AK; Amit A; Singh RP; Sonkar SC; Chaturvedi N; Shukla D; Vishvakarma NK
  • Eur J Pharmacol 2020[Nov]; 886 (ä): 173551 PMID32931783show ga
  • The severity of the recent pandemic and the absence of any specific medication impelled the identification of existing drugs with potential in the treatment of Coronavirus disease-2019 (COVID-19), caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). Curcumin, known for its pharmacological abilities especially as an anti-inflammatory agent, can be hypothesized as a potential candidate in the therapeutic regimen. COVID-19 has an assorted range of pathophysiological consequences, including pulmonary damage, elevated inflammatory response, coagulopathy, and multi-organ damage. This review summarizes the several evidences for the pharmacological benefits of curcumin in COVID-19-associated clinical manifestations. Curcumin can be appraised to hinder cellular entry, replication of SARS-CoV-2, and to prevent and repair COVID-19-associated damage of pneumocytes, renal cells, cardiomyocytes, hematopoietic stem cells, etc. The modulation and protective effect of curcumin on cytokine storm-related disorders are also discussed. Collectively, this review provides grounds for its clinical evaluation in the therapeutic management of SARS-CoV-2 infection.
  • |Animals[MESH]
  • |Betacoronavirus/drug effects/physiology[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*drug therapy/virology[MESH]
  • |Curcumin/adverse effects/*pharmacology/therapeutic use[MESH]
  • |Humans[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*drug therapy/virology[MESH]
  • |SARS-CoV-2[MESH]


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