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10.1093/pubmed/fdaa158

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32930793!7543419!32930793
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suck abstract from ncbi


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pmid32930793      J+Public+Health+(Oxf) 2021 ; 43 (1): 35-41
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  • Risk of severe coronavirus disease in imported and secondary cases in Zhejiang province, China #MMPMID32930793
  • He F; Shang X; Fu T; Lin J; Li F; Qiu Y; Wu C; Wang Z
  • J Public Health (Oxf) 2021[Apr]; 43 (1): 35-41 PMID32930793show ga
  • BACKGROUND: To our knowledge, no previous studies have focused on determining whether the virulence and case fatality rate of the severe acute respiratory coronavirus 2 (SARS-CoV-2) decreases as the virus continues to spread. Hence, our aim was to retrospectively explore the differences in the risk of severe or critical COVID-19 among imported, secondary and tertiary cases in Zhejiang, China. METHODS: We categorized COVID-19 cases reported by hospitals in Zhejiang as first-, second- and third-generation cases. Univariate and multivariate logistic regression analyses were performed to compare disease severity and case generation. RESULTS: Of 1187 COVID-19 cases, 227 (19.1%, 95% CI: 16.9-21.4) manifested severe or critical illness. The adjusted risk difference for severe or critical illness was lower for second- (odds ratio (OR) = 0.84, 95% confidence interval (CI): 0.52-1.36) and third-generation (OR = 0.55, 95% CI: 0.37-0.83) cases than for first-generation cases. Compared with hospitalized patients, cases identified at centralized isolation locations (OR = 0.62, 95% CI: 0.40-0.97) and those identified through active search or gateway screening (OR = 0.28, 95% CI: 0.08-1.04) were at a lower risk of severe or critical illness. CONCLUSIONS: Second- and third-generation cases of COVID-19 have a lower risk of developing severe or critical illness than first-generation cases.
  • |*COVID-19/classification/epidemiology[MESH]
  • |*Severity of Illness Index[MESH]
  • |Adult[MESH]
  • |Age Factors[MESH]
  • |Aged[MESH]
  • |Analysis of Variance[MESH]
  • |China/epidemiology[MESH]
  • |Disease Progression[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Incidence[MESH]
  • |Logistic Models[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Retrospective Studies[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2[MESH]


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