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10.1002/JLB.5COVA0720-421RR http://scihub22266oqcxt.onion/10.1002/JLB.5COVA0720-421RR 32930458!10016821!32930458     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Leukoc+Biol 2021 ; 109 (1): 91-97 Nephropedia Template TP {{tp|p=32930458|t=2021. Regulatory CD4(+) and CD8(+) T cells are negatively correlated with CD4(+) /CD8(+) T cell ratios in patients acutely infected with SARS-CoV-2 |pdf=|usr=}}{{32930458}} gab.com Text Regulatory CD4(+) and CD8(+) T cells are negatively correlated with CD4(+) /CD8(+) T cell ratios in patients acutely infected with SARS-CoV-2 JO: J Leukoc Biol http://www.kidney.de/pget.php?&tw=1&pmid=32930458 #FOAvip Regulatory T cell can protect against severe forms of coronaviral infections attributable to host inflammatory responses. But its role in the pathogenesis of COVID-19 is still unclear. In this study, frequencies of total and multiple subsets of lymphocytes in peripheral blood of COVID-19 patients and discharged individuals were analyzed using a multicolor flow cytometry assay. Plasma concentration of IL-10 was measured using a microsphere-based immunoassay kit. Comparing to healthy controls, the frequencies of total lymphocytes and T cells decreased significantly in both acutely infected COVID-19 patients and discharged individuals. The frequencies of total lymphocytes correlated negatively with the frequencies of CD3(-) CD56(+) NK cells. The frequencies of regulatory CD8(+) CD25(+) T cells correlated with CD4(+) /CD8(+) T cell ratios positively, while the frequencies of regulatory CD4(+) CD25(+) CD127(-) T cells correlated negatively with CD4(+) /CD8(+) T cell ratios. Ratios of CD4(+) /CD8(+) T cells increased significantly in patients beyond age of 45 years. And accordingly, the frequencies of regulatory CD8(+) CD25(+) T cells were also found significantly increased in these patients. Collectively, the results suggest that regulatory CD4(+) and CD8(+) T cells may play distinct roles in the pathogenesis of COVID-19. Moreover, the data indicate that NK cells might contribute to the COVID-19 associated lymphopenia. Twit Text FOAVip Regulatory CD4(+) and CD8(+) T cells are negatively correlated with CD4(+) /CD8(+) T cell ratios in patients acutely infected with SARS-CoV-2 ????J Leukoc Biol http://www.kidney.de/pget.php?&tw=1&pmid=32930458 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32930458 #FOAvip English Wikipedia <ref>{{Cite pmid|32930458}}</ref> Regulatory CD4(+) and CD8(+) T cells are negatively correlated with CD4(+) /CD8(+) T cell ratios in patients acutely infected with SARS-CoV-2 #MMPMID32930458 Gao M; Liu Y; Guo M; Wang Q; Wang Y; Fan J; Shen Y; Hou J; Wan Y; Zhu Z J Leukoc Biol 2021[Jan]; 109 (1): 91-97 PMID32930458show ga Regulatory T cell can protect against severe forms of coronaviral infections attributable to host inflammatory responses. But its role in the pathogenesis of COVID-19 is still unclear. In this study, frequencies of total and multiple subsets of lymphocytes in peripheral blood of COVID-19 patients and discharged individuals were analyzed using a multicolor flow cytometry assay. Plasma concentration of IL-10 was measured using a microsphere-based immunoassay kit. Comparing to healthy controls, the frequencies of total lymphocytes and T cells decreased significantly in both acutely infected COVID-19 patients and discharged individuals. The frequencies of total lymphocytes correlated negatively with the frequencies of CD3(-) CD56(+) NK cells. The frequencies of regulatory CD8(+) CD25(+) T cells correlated with CD4(+) /CD8(+) T cell ratios positively, while the frequencies of regulatory CD4(+) CD25(+) CD127(-) T cells correlated negatively with CD4(+) /CD8(+) T cell ratios. Ratios of CD4(+) /CD8(+) T cells increased significantly in patients beyond age of 45 years. And accordingly, the frequencies of regulatory CD8(+) CD25(+) T cells were also found significantly increased in these patients. Collectively, the results suggest that regulatory CD4(+) and CD8(+) T cells may play distinct roles in the pathogenesis of COVID-19. Moreover, the data indicate that NK cells might contribute to the COVID-19 associated lymphopenia. |*CD8-Positive T-Lymphocytes/immunology/metabolism/pathology[MESH] |*COVID-19/blood/immunology/pathology[MESH] |*SARS-CoV-2/immunology/metabolism[MESH] |*T-Lymphocytes, Regulatory/immunology/metabolism/pathology[MESH] |Adult[MESH] |Aged[MESH] |Antigens, CD/blood/immunology[MESH] |CD4-CD8 Ratio[MESH] |Female[MESH] |Humans[MESH] |Killer Cells, Natural/immunology/pathology[MESH] |Male[MESH]Regulatory CD4(+) and CD8(+) T cells are negatively correlated with CD(epmc).pdf DeepDyve Pubget Overpricing