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10.1073/pnas.2007814117 http://scihub22266oqcxt.onion/10.1073/pnas.2007814117 32929007!7533697!32929007     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2020 ; 117 (39): 24464-24474 Nephropedia Template TP {{tp|p=32929007|t=2020. Microglia depletion exacerbates demyelination and impairs remyelination in a neurotropic coronavirus infection |pdf=|usr=}}{{32929007}} gab.com Text Microglia depletion exacerbates demyelination and impairs remyelination in a neurotropic coronavirus infection JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=32929007 #FOAvip Microglia are considered both pathogenic and protective during recovery from demyelination, but their precise role remains ill defined. Here, using an inhibitor of colony stimulating factor 1 receptor (CSF1R), PLX5622, and mice infected with a neurotropic coronavirus (mouse hepatitis virus [MHV], strain JHMV), we show that depletion of microglia during the time of JHMV clearance resulted in impaired myelin repair and prolonged clinical disease without affecting the kinetics of virus clearance. Microglia were required only during the early stages of remyelination. Notably, large deposits of extracellular vesiculated myelin and cellular debris were detected in the spinal cords of PLX5622-treated and not control mice, which correlated with decreased numbers of oligodendrocytes in demyelinating lesions in drug-treated mice. Furthermore, gene expression analyses demonstrated differential expression of genes involved in myelin debris clearance, lipid and cholesterol recycling, and promotion of oligodendrocyte function. The results also demonstrate that microglial functions affected by depletion could not be compensated by infiltrating macrophages. Together, these results demonstrate that microglia play key roles in debris clearance and in the initiation of remyelination following infection with a neurotropic coronavirus but are not necessary during later stages of remyelination. Twit Text FOAVip Microglia depletion exacerbates demyelination and impairs remyelination in a neurotropic coronavirus infection ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=32929007 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32929007 #FOAvip English Wikipedia <ref>{{Cite pmid|32929007}}</ref> Microglia depletion exacerbates demyelination and impairs remyelination in a neurotropic coronavirus infection #MMPMID32929007 Sariol A; Mackin S; Allred MG; Ma C; Zhou Y; Zhang Q; Zou X; Abrahante JE; Meyerholz DK; Perlman S Proc Natl Acad Sci U S A 2020[Sep]; 117 (39): 24464-24474 PMID32929007show ga Microglia are considered both pathogenic and protective during recovery from demyelination, but their precise role remains ill defined. Here, using an inhibitor of colony stimulating factor 1 receptor (CSF1R), PLX5622, and mice infected with a neurotropic coronavirus (mouse hepatitis virus [MHV], strain JHMV), we show that depletion of microglia during the time of JHMV clearance resulted in impaired myelin repair and prolonged clinical disease without affecting the kinetics of virus clearance. Microglia were required only during the early stages of remyelination. Notably, large deposits of extracellular vesiculated myelin and cellular debris were detected in the spinal cords of PLX5622-treated and not control mice, which correlated with decreased numbers of oligodendrocytes in demyelinating lesions in drug-treated mice. Furthermore, gene expression analyses demonstrated differential expression of genes involved in myelin debris clearance, lipid and cholesterol recycling, and promotion of oligodendrocyte function. The results also demonstrate that microglial functions affected by depletion could not be compensated by infiltrating macrophages. Together, these results demonstrate that microglia play key roles in debris clearance and in the initiation of remyelination following infection with a neurotropic coronavirus but are not necessary during later stages of remyelination. |*Remyelination/genetics[MESH] |Animals[MESH] |Coronavirus Infections/immunology/*pathology/virology[MESH] |Demyelinating Diseases/immunology/*pathology/virology[MESH] |Disease Models, Animal[MESH] |Female[MESH] |Gene Expression Regulation[MESH] |Immunity, Cellular/drug effects[MESH] |Inflammation[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Microglia/drug effects/metabolism/*pathology[MESH] |Murine hepatitis virus/drug effects/physiology[MESH] |Myelin Sheath/metabolism/pathology[MESH] |Oligodendroglia/pathology[MESH] |Organic Chemicals/administration & dosage/adverse effects[MESH] |Receptors, Granulocyte-Macrophage Colony-Stimulating Factor/antagonists & inhibitors[MESH]Microglia depletion exacerbates demyelination and impairs remyelinatio(epmc).pdf DeepDyve Pubget Overpricing