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10.3390/molecules25184133

http://scihub22266oqcxt.onion/10.3390/molecules25184133
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32927621!7571139!32927621
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suck abstract from ncbi


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pmid32927621      Molecules 2020 ; 25 (18): ä
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  • Mass Spectrometry and Structural Biology Techniques in the Studies on the Coronavirus-Receptor Interaction #MMPMID32927621
  • Witkowska D
  • Molecules 2020[Sep]; 25 (18): ä PMID32927621show ga
  • Mass spectrometry and some other biophysical methods, have made substantial contributions to the studies on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and human proteins interactions. The most interesting feature of SARS-CoV-2 seems to be the structure of its spike (S) protein and its interaction with the human cell receptor. Mass spectrometry of spike S protein revealed how the glycoforms are distributed across the S protein surface. X-ray crystallography and cryo-electron microscopy made huge impact on the studies on the S protein and ACE2 receptor protein interaction, by elucidating the three-dimensional structures of these proteins and their conformational changes. The findings of the most recent studies in the scope of SARS-CoV-2-Human protein-protein interactions are described here.
  • |*Pandemics[MESH]
  • |Amino Acid Sequence[MESH]
  • |Angiotensin-Converting Enzyme 2[MESH]
  • |Betacoronavirus/*chemistry/pathogenicity[MESH]
  • |Binding Sites[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*epidemiology/virology[MESH]
  • |Gene Expression[MESH]
  • |Host-Pathogen Interactions[MESH]
  • |Humans[MESH]
  • |Models, Molecular[MESH]
  • |Peptidyl-Dipeptidase A/*chemistry/genetics/metabolism[MESH]
  • |Pneumonia, Viral/*epidemiology/virology[MESH]
  • |Protein Binding[MESH]
  • |Protein Conformation, alpha-Helical[MESH]
  • |Protein Conformation, beta-Strand[MESH]
  • |Protein Interaction Domains and Motifs[MESH]
  • |Receptors, Virus/*chemistry/genetics/metabolism[MESH]
  • |SARS-CoV-2[MESH]
  • |Sequence Alignment[MESH]
  • |Severe Acute Respiratory Syndrome/*epidemiology/virology[MESH]
  • |Severe acute respiratory syndrome-related coronavirus/chemistry/pathogenicity[MESH]


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