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10.1002/jmv.26515

http://scihub22266oqcxt.onion/10.1002/jmv.26515
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32926424!ä!32926424

suck abstract from ncbi


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pmid32926424      J+Med+Virol 2021 ; 93 (3): 1639-1651
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  • Low serum calcium and phosphorus and their clinical performance in detecting COVID-19 patients #MMPMID32926424
  • Yang C; Ma X; Wu J; Han J; Zheng Z; Duan H; Liu Q; Wu C; Dong Y; Dong L
  • J Med Virol 2021[Mar]; 93 (3): 1639-1651 PMID32926424show ga
  • This study aimed to evaluate the clinical performance of low serum calcium and phosphorus in discriminative diagnosis of the severity of patients with coronavirus disease 2019 (COVID-19). We conducted a single-center hospital-based study and consecutively recruited 122 suspected and 104 confirmed patients with COVID-19 during January 24 to April 25, 2020. Clinical risk factors of COVID-19 were identified. The discriminative power of low calcium and phosphorus regarding the disease severity was evaluated. Low calcium and low phosphorus are more prevalent in severe or critical COVID-19 patients than moderate COVID-19 patients (odds ratio [OR], 15.07; 95% confidence interval [CI], 1.59-143.18 for calcium; OR, 6.90; 95% CI, 2.43-19.64 for phosphorus). The specificity in detecting the severe or critical patients among COVID-19 patients reached 98.5% (95% CI, 92.0%-99.7%) and 84.8% (95% CI, 74.3%-91.6%) by low calcium and low phosphorus, respectively, albeit with suboptimal sensitivity. Calcium and phosphorus combined with lymphocyte count could obtain the best discriminative performance for the severe COVID-19 patients (area under the curve [AUC] = 0.80), and combined with oxygenation index was promising (AUC = 0.71). Similar discriminative performances of low calcium and low phosphorus were found between suspected and confirmed COVID-19 patient. Low calcium and low phosphorus could indicate the severity of COVID-19 patients, and may be utilized as promising clinical biomarkers for discriminative diagnosis.
  • |Adult[MESH]
  • |Biomarkers/blood[MESH]
  • |COVID-19/*blood/*diagnosis[MESH]
  • |Calcium/*blood[MESH]
  • |China[MESH]
  • |Comorbidity[MESH]
  • |Humans[MESH]
  • |Lymphocyte Count[MESH]
  • |Middle Aged[MESH]
  • |Phosphorus/*blood[MESH]
  • |Prognosis[MESH]
  • |Retrospective Studies[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2[MESH]


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