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10.1097/TA.0000000000002939 http://scihub22266oqcxt.onion/10.1097/TA.0000000000002939 32925581!7687875!32925581     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Trauma+Acute+Care+Surg 2020 ; 89 (6): 1092-1098 Nephropedia Template TP {{tp|p=32925581|t=2020. Timing of invasive mechanic ventilation in critically ill patients with coronavirus disease 2019 |pdf=|usr=}}{{32925581}} gab.com Text Timing of invasive mechanic ventilation in critically ill patients with coronavirus disease 2019 JO: J Trauma Acute Care Surg http://www.kidney.de/pget.php?&tw=1&pmid=32925581 #FOAvip BACKGROUND: Invasive mechanical ventilation (IMV) is a lifesaving strategy for critically ill patients with coronavirus disease 2019 (COVID-19). We aim to report the case series of critical patients receiving IMV in Wuhan and to discuss the timing of IMV in these patients. METHODS: Data of 657 patients admitted to emergency intensive care unit of Zhongnan Hospital and isolated isolation wards of Wuhan Union Hospital from January 1 to March 10, 2020, were retrospectively reviewed. All medical records of 40 COVID-19 patients who required IMV were collected at different time points, including baseline (at admission), before receiving IMV, and before death or hospital discharge. RESULTS: Among 40 COVID-19 patients with IMV, 31 died, and 9 survived and was discharged. The median age was 70 years (interquartile range [IQR], 62-76 years), and nonsurvivors were older than survivors. The median period from the noninvasive mechanic ventilation (NIV) or high-flow nasal cannula oxygen therapy (HFNC) to intubation was 7 hours (IQR, 2-42 hours) in IMV survivors and 54 hours (IQR, 28-143 hours) in IMV nonsurvivors. We observed that, when the time interval from NIV/HFNC to intubation was less than 50 hours (about 2 calendar days), together with Acute Physiology and Chronic Health Evaluation II (APACHE II) score of less than 10 or pneumonia severity index (PSI) score of less than 100, mortality can be reduced to 60% or less. Prolonged interval from NIV/HFNC to intubation and high levels of APACHE II and PSI before intubation were associated with higher mortality in critically ill patients. Multiple organ damage was common among these nonsurvivors in the course of treatment. CONCLUSION: Early initial intubation after NIV/HFNC might have a beneficial effect in reducing mortality for critically ill patients meeting IMV indication. Considering APACHE II and PSI scores might help physicians in decision making about timing of intubation for curbing subsequent mortality. LEVEL OF EVIDENCE: Therapeutic, level V. Twit Text FOAVip Timing of invasive mechanic ventilation in critically ill patients with coronavirus disease 2019 ????J Trauma Acute Care Surg http://www.kidney.de/pget.php?&tw=1&pmid=32925581 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32925581 #FOAvip English Wikipedia <ref>{{Cite pmid|32925581}}</ref> Timing of invasive mechanic ventilation in critically ill patients with coronavirus disease 2019 #MMPMID32925581 Zhang Q; Shen J; Chen L; Li S; Zhang W; Jiang C; Ma H; Lin L; Zheng X; Zhao Y J Trauma Acute Care Surg 2020[Dec]; 89 (6): 1092-1098 PMID32925581show ga BACKGROUND: Invasive mechanical ventilation (IMV) is a lifesaving strategy for critically ill patients with coronavirus disease 2019 (COVID-19). We aim to report the case series of critical patients receiving IMV in Wuhan and to discuss the timing of IMV in these patients. METHODS: Data of 657 patients admitted to emergency intensive care unit of Zhongnan Hospital and isolated isolation wards of Wuhan Union Hospital from January 1 to March 10, 2020, were retrospectively reviewed. All medical records of 40 COVID-19 patients who required IMV were collected at different time points, including baseline (at admission), before receiving IMV, and before death or hospital discharge. RESULTS: Among 40 COVID-19 patients with IMV, 31 died, and 9 survived and was discharged. The median age was 70 years (interquartile range [IQR], 62-76 years), and nonsurvivors were older than survivors. The median period from the noninvasive mechanic ventilation (NIV) or high-flow nasal cannula oxygen therapy (HFNC) to intubation was 7 hours (IQR, 2-42 hours) in IMV survivors and 54 hours (IQR, 28-143 hours) in IMV nonsurvivors. We observed that, when the time interval from NIV/HFNC to intubation was less than 50 hours (about 2 calendar days), together with Acute Physiology and Chronic Health Evaluation II (APACHE II) score of less than 10 or pneumonia severity index (PSI) score of less than 100, mortality can be reduced to 60% or less. Prolonged interval from NIV/HFNC to intubation and high levels of APACHE II and PSI before intubation were associated with higher mortality in critically ill patients. Multiple organ damage was common among these nonsurvivors in the course of treatment. CONCLUSION: Early initial intubation after NIV/HFNC might have a beneficial effect in reducing mortality for critically ill patients meeting IMV indication. Considering APACHE II and PSI scores might help physicians in decision making about timing of intubation for curbing subsequent mortality. LEVEL OF EVIDENCE: Therapeutic, level V. |*Hospital Mortality[MESH] |APACHE[MESH] |Aged[MESH] |Betacoronavirus[MESH] |COVID-19[MESH] |China[MESH] |Coronavirus Infections/mortality/*therapy[MESH] |Critical Illness/mortality/*therapy[MESH] |Female[MESH] |Hospitalization[MESH] |Humans[MESH] |Intensive Care Units[MESH] |Male[MESH] |Middle Aged[MESH] |Noninvasive Ventilation/*methods[MESH] |Oxygen Inhalation Therapy/methods[MESH] |Oxygen/*administration & dosage[MESH] |Pandemics[MESH] |Pneumonia, Viral/mortality/*therapy[MESH] |Retrospective Studies[MESH] |SARS-CoV-2[MESH]Timing of invasive mechanic ventilation in critically ill patients wit(epmc).pdf DeepDyve Pubget Overpricing