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10.7150/ijms.47587

http://scihub22266oqcxt.onion/10.7150/ijms.47587
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32922203!7484640!32922203
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suck abstract from ncbi


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pmid32922203      Int+J+Med+Sci 2020 ; 17 (15): 2373-2378
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  • CT features and outcomes of newly developed pulmonary lesions in patients with Coronavirus Disease 2019 (COVID-19) #MMPMID32922203
  • Li WJ; Lv ZM; Lv FJ; Fu B; Hu LB; Chu ZG
  • Int J Med Sci 2020[]; 17 (15): 2373-2378 PMID32922203show ga
  • Background: In patients with coronavirus disease 2019 (COVID-19) pneumonia, whether new pulmonary lesions will continue to develop after treatment was unknown. This study aimed to determine whether new pulmonary lesions will develop after treatment in patients with COVID-19 pneumonia, and investigate their CT features and outcomes. Methods: This retrospective study included 56 consecutive patients with confirmed COVID-19 pneumonia from January 20 to March 5, 2020. Their initial and follow-up CT images and clinical data were reviewed. The CT manifestations of primary and newly developed pulmonary lesions and their changes after treatment were mainly evaluated. Results: Among the 56 patients (mean age: 48+/-15 years, 35 men) with COVID-19 pneumonia, 42 (75.0%) patients developed new pulmonary lesions during treatment. All new lesions developed before the nucleic acid test turned negative. Patients with new lesions were more likely to have lymphopenia (P=0.041) or increased C-reactive protein (CRP) levels (P<0.001) than those without new lesions. Of the 42 patients, 30 (71.4%) patients developed new lesions once, and 12 (28.6%) twice or thrice, which usually appeared when primary lesions were progressing (37, 88.1%) and 1-15 days after treatment. The newly developed lesions were usually multiple (38, 90.5%), distributed in the previously involved (39, 92.9%) or uninvolved (27, 64.3%) lobes, and manifested as ground-glass opacities (GGOs) with consolidation (23, 54.8%) or pure GGOs (19, 45.2%). After their occurrence, the new lesions in most patients (32, 76.2%) showed direct absorption, whereas those in some patients (10, 23.8%) progressed before absorption. Conclusion: During treatment, most patients with COVID-19 pneumonia will develop new pulmonary lesions, which usually manifest as multiple GGOs distributed around the primary lesions or in previously uninvolved lobes, and are subsequently absorbed directly.
  • |Adult[MESH]
  • |Betacoronavirus/genetics/*isolation & purification/pathogenicity[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Testing[MESH]
  • |Clinical Laboratory Techniques/*statistics & numerical data[MESH]
  • |Coronavirus Infections/diagnosis/*mortality/therapy/virology[MESH]
  • |Disease Progression[MESH]
  • |Female[MESH]
  • |Follow-Up Studies[MESH]
  • |Humans[MESH]
  • |Lung/*diagnostic imaging[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/diagnosis/*mortality/therapy/virology[MESH]
  • |RNA, Viral/isolation & purification[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2[MESH]


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