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10.1007/s11033-020-05830-8 http://scihub22266oqcxt.onion/10.1007/s11033-020-05830-8 32920757!7486968!32920757     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Biol+Rep 2020 ; 47 (10): 8229-8233 Nephropedia Template TP {{tp|p=32920757|t=2020. Role of melatonin in the treatment of COVID-19; as an adjuvant through cluster differentiation 147 (CD147) |pdf=|usr=}}{{32920757}} gab.com Text Role of melatonin in the treatment of COVID-19; as an adjuvant through cluster differentiation 147 (CD147) JO: Mol Biol Rep http://www.kidney.de/pget.php?&tw=1&pmid=32920757 #FOAvip COVID-19 caused by the SARS-CoV-2 outbreak quickly has turned into a pandemic. However, no specific antiviral agent is yet available. In this communication, we aimed to evaluate the significance of CD147 protein and the potential protective effect of melatonin that is mediated by this protein in COVID-19. CD147 is a glycoprotein that is responsible for the cytokine storm in the lungs through the mediation of viral invasion. Melatonin use previously was shown to reduce cardiac damage by blocking the CD147 activity. Hence, melatonin, a safe drug, may prevent severe symptoms, reduce symptom severity and the adverse effects of the other antiviral drugs in COVID-19 patients. In conclusion, the use of melatonin, which is reduced in the elderly and immune-compromised patients, should be considered as an adjuvant through its CD147 suppressor and immunomodulatory effect. Twit Text FOAVip Role of melatonin in the treatment of COVID-19; as an adjuvant through cluster differentiation 147 (CD147) ????Mol Biol Rep http://www.kidney.de/pget.php?&tw=1&pmid=32920757 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32920757 #FOAvip English Wikipedia <ref>{{Cite pmid|32920757}}</ref> Role of melatonin in the treatment of COVID-19; as an adjuvant through cluster differentiation 147 (CD147) #MMPMID32920757 Sehirli AO; Sayiner S; Serakinci N Mol Biol Rep 2020[Oct]; 47 (10): 8229-8233 PMID32920757show ga COVID-19 caused by the SARS-CoV-2 outbreak quickly has turned into a pandemic. However, no specific antiviral agent is yet available. In this communication, we aimed to evaluate the significance of CD147 protein and the potential protective effect of melatonin that is mediated by this protein in COVID-19. CD147 is a glycoprotein that is responsible for the cytokine storm in the lungs through the mediation of viral invasion. Melatonin use previously was shown to reduce cardiac damage by blocking the CD147 activity. Hence, melatonin, a safe drug, may prevent severe symptoms, reduce symptom severity and the adverse effects of the other antiviral drugs in COVID-19 patients. In conclusion, the use of melatonin, which is reduced in the elderly and immune-compromised patients, should be considered as an adjuvant through its CD147 suppressor and immunomodulatory effect. |Adjuvants, Pharmaceutic/*therapeutic use[MESH] |Animals[MESH] |Antioxidants/metabolism[MESH] |Antiviral Agents/pharmacology/*therapeutic use[MESH] |Basigin/antagonists & inhibitors/*metabolism[MESH] |COVID-19[MESH] |Coronavirus Infections/*drug therapy/metabolism[MESH] |Humans[MESH] |Immune System/drug effects[MESH] |Melatonin/pharmacology/*therapeutic use[MESH] |Pandemics[MESH] |Pneumonia, Viral/*drug therapy/metabolism[MESH]Role of melatonin in the treatment of COVID-19; as an adjuvant through(epmc).pdf DeepDyve Pubget Overpricing