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Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Clin+Virol 2020 ; 132 (ä): 104618 Nephropedia Template TP
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Performance evaluation of two SARS-CoV-2 IgG/IgM rapid tests (Covid-Presto and NG-Test) and one IgG automated immunoassay (Abbott) #MMPMID32919222
J Clin Virol 2020[Nov]; 132 (ä): 104618 PMID32919222show ga
The aim of this study was to assess the analytical performances, sensitivity and specificity, of two rapid tests (Covid- Presto(R) test rapid Covid-19 IgG/IgM and NG-Test(R) IgM-IgG COVID-19) and one automated immunoassay (Abbott SARS-CoV-2 IgG) for detecting anti- SARS-CoV-2 antibodies. This study was performed with: (i) a positive panel constituted of 88 SARS-CoV-2 specimens collected from patients with a positive SARS-CoV-2 RT-PCR, and (ii) a negative panel of 120 serum samples, all collected before November 2019, including 64 samples with a cross-reactivity panel. Sensitivity of Covid-Presto(R) test for IgM and IgG was 78.4% and 92.0%, respectively. Sensitivity of NG-Test(R) for IgM and IgG was 96.6% and 94.9%, respectively. Sensitivity of Abbott IgG assay was 96.5% showing an excellent agreement with the two rapid tests (kappa = 0.947 and kappa = 0.936 for NGTest (R) and Covid-Presto(R) test, respectively). An excellent agreement was also observed between the two rapid tests (kappa = 0.937). Specificity for IgM was 100% and 86.5% for Covid-Presto(R) test and NG-Test(R), respectively. Specificity for IgG was 92.0%, 94.9% and 96.5% for Covid-Presto(R), NGTest (R), and Abbott, respectively. Most of the false positive results observed with NG-Test(R) resulted from samples containing malarial antibodies. In conclusion, performances of these 2 rapid tests are very good and comparable to those obtained with automated immunoassay, except for IgM specificity with the NG-Test(R). Thus, isolated IgM should be cautiously interpreted due to the possible false-positive reactions with this test. Finally, before their large use, the rapid tests must be reliably evaluated with adequate and large panel including early seroconversion and possible cross-reactive samples.