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10.1093/jpids/piaa115 http://scihub22266oqcxt.onion/10.1093/jpids/piaa115 32918548!7543452!32918548     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32918548&cmd=llinks): Failed to open stream: HTTP request failed! 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Multicenter Interim Guidance on Use of Antivirals for Children With Coronavirus Disease 2019/Severe Acute Respiratory Syndrome Coronavirus 2 |pdf=|usr=}}{{32918548}} gab.com Text Multicenter Interim Guidance on Use of Antivirals for Children With Coronavirus Disease 2019/Severe Acute Respiratory Syndrome Coronavirus 2 JO: J Pediatric Infect Dis Soc http://www.kidney.de/pget.php?&tw=1&pmid=32918548 #FOAvip BACKGROUND: Although coronavirus disease 2019 (COVID-19) is a mild infection in most children, a small proportion develop severe or critical illness. Data describing agents with potential antiviral activity continue to expand such that updated guidance is needed regarding use of these agents in children. METHODS: A panel of pediatric infectious diseases physicians and pharmacists from 20 geographically diverse North American institutions was convened. Through a series of teleconferences and web-based surveys, a set of guidance statements was developed and refined based on review of the best available evidence and expert opinion. RESULTS: Given the typically mild course of COVID-19 in children, supportive care alone is suggested for most cases. For children with severe illness, defined as a supplemental oxygen requirement without need for noninvasive or invasive mechanical ventilation or extracorporeal membrane oxygenation (ECMO), remdesivir is suggested, preferably as part of a clinical trial if available. Remdesivir should also be considered for critically ill children requiring invasive or noninvasive mechanical ventilation or ECMO. A duration of 5 days is appropriate for most patients. The panel recommends against the use of hydroxychloroquine or lopinavir-ritonavir (or other protease inhibitors) for COVID-19 in children. CONCLUSIONS: Antiviral therapy for COVID-19 is not necessary for the great majority of pediatric patients. For children with severe or critical disease, this guidance offers an approach for decision-making regarding use of remdesivir. Twit Text FOAVip Multicenter Interim Guidance on Use of Antivirals for Children With Coronavirus Disease 2019/Severe Acute Respiratory Syndrome Coronavirus 2 ????J Pediatric Infect Dis Soc http://www.kidney.de/pget.php?&tw=1&pmid=32918548 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32918548 #FOAvip English Wikipedia <ref>{{Cite pmid|32918548}}</ref> Multicenter Interim Guidance on Use of Antivirals for Children With Coronavirus Disease 2019/Severe Acute Respiratory Syndrome Coronavirus 2 #MMPMID32918548 Chiotos K; Hayes M; Kimberlin DW; Jones SB; James SH; Pinninti SG; Yarbrough A; Abzug MJ; MacBrayne CE; Soma VL; Dulek DE; Vora SB; Waghmare A; Wolf J; Olivero R; Grapentine S; Wattier RL; Bio L; Cross SJ; Dillman NO; Downes KJ; Oliveira CR; Timberlake K; Young J; Orscheln RC; Tamma PD; Schwenk HT; Zachariah P; Aldrich ML; Goldman DL; Groves HE; Rajapakse NS; Lamb GS; Tribble AC; Hersh AL; Thorell EA; Denison MR; Ratner AJ; Newland JG; Nakamura MM J Pediatric Infect Dis Soc 2021[Feb]; 10 (1): 34-48 PMID32918548show ga BACKGROUND: Although coronavirus disease 2019 (COVID-19) is a mild infection in most children, a small proportion develop severe or critical illness. Data describing agents with potential antiviral activity continue to expand such that updated guidance is needed regarding use of these agents in children. METHODS: A panel of pediatric infectious diseases physicians and pharmacists from 20 geographically diverse North American institutions was convened. Through a series of teleconferences and web-based surveys, a set of guidance statements was developed and refined based on review of the best available evidence and expert opinion. RESULTS: Given the typically mild course of COVID-19 in children, supportive care alone is suggested for most cases. For children with severe illness, defined as a supplemental oxygen requirement without need for noninvasive or invasive mechanical ventilation or extracorporeal membrane oxygenation (ECMO), remdesivir is suggested, preferably as part of a clinical trial if available. Remdesivir should also be considered for critically ill children requiring invasive or noninvasive mechanical ventilation or ECMO. A duration of 5 days is appropriate for most patients. The panel recommends against the use of hydroxychloroquine or lopinavir-ritonavir (or other protease inhibitors) for COVID-19 in children. CONCLUSIONS: Antiviral therapy for COVID-19 is not necessary for the great majority of pediatric patients. For children with severe or critical disease, this guidance offers an approach for decision-making regarding use of remdesivir. |*COVID-19 Drug Treatment[MESH] |Adenosine Monophosphate/analogs & derivatives/therapeutic use[MESH] |Alanine/analogs & derivatives/therapeutic use[MESH] |Antiviral Agents/*therapeutic use[MESH] |COVID-19/therapy[MESH] |Child[MESH] |Evidence-Based Medicine[MESH] |Humans[MESH] |Immunocompromised Host[MESH] |Risk Factors[MESH] |Severity of Illness Index[MESH]Multicenter Interim Guidance on Use of Antivirals for Children With Co(epmc).pdf DeepDyve Pubget Overpricing