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10.7861/clinmed.2020-0555

http://scihub22266oqcxt.onion/10.7861/clinmed.2020-0555
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32917746!7687334!32917746
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suck abstract from ncbi


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pmid32917746      Clin+Med+(Lond) 2020 ; 20 (6): e209-e211
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  • The clinical sensitivity of a single SARS-CoV-2 upper respiratory tract RT-PCR test for diagnosing COVID-19 using convalescent antibody as a comparator #MMPMID32917746
  • Holborow A; Asad H; Porter L; Tidswell P; Johnston C; Blyth I; Bone A; Healy B
  • Clin Med (Lond) 2020[Nov]; 20 (6): e209-e211 PMID32917746show ga
  • The clinical false negative rate of reverse transcriptase polymerase chain reaction (RT-PCR) testing for SARS-CoV-2 on a single upper respiratory tract sample was calculated using convalescent antibody testing as a comparator. The sensitivity in symptomatic individuals was 86.2% (25/29). Of the missed cases, one (3.5%) was detected by repeat RT-PCR, one by CT thorax and two (7.1%) by convalescent antibody. The clinical false negative rate of a single RT-PCR on an upper respiratory tract sample of 14% in symptomatic patients is reassuring when compared to early reports. This report supports a strategy of combining repeat swabbing, use of acute and convalescent antibody testing and CT thorax for COVID-19 diagnosis.
  • |*Clinical Laboratory Techniques/standards/statistics & numerical data[MESH]
  • |*Reverse Transcriptase Polymerase Chain Reaction/standards/statistics & numerical data[MESH]
  • |Antibodies, Viral/blood[MESH]
  • |Asymptomatic Infections[MESH]
  • |Betacoronavirus/genetics[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Testing[MESH]
  • |Coronavirus Infections/blood/*diagnosis/immunology/virology[MESH]
  • |False Negative Reactions[MESH]
  • |Humans[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/blood/*diagnosis/immunology/virology[MESH]
  • |SARS-CoV-2[MESH]
  • |Sensitivity and Specificity[MESH]


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