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10.3390/ph13090238

http://scihub22266oqcxt.onion/10.3390/ph13090238
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suck abstract from ncbi


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pmid32916949      Pharmaceuticals+(Basel) 2020 ; 13 (9): ä
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  • Can Nuclear Imaging of Activated Macrophages with Folic Acid-Based Radiotracers Serve as a Prognostic Means to Identify COVID-19 Patients at Risk? #MMPMID32916949
  • Muller C; Schibli R; Maurer B
  • Pharmaceuticals (Basel) 2020[Sep]; 13 (9): ä PMID32916949show ga
  • Herein, we discuss the potential role of folic acid-based radiopharmaceuticals for macrophage imaging to support clinical decision-making in patients with COVID-19. Activated macrophages play an important role during coronavirus infections. Exuberant host responses, i.e., a cytokine storm with increase of macrophage-related cytokines, such as TNFalpha, IL-1beta, and IL-6 can lead to life-threatening complications, such as acute respiratory distress syndrome (ARDS), which develops in approximately 20% of the patients. Diverse immune modulating therapies are currently being tested in clinical trials. In a preclinical proof-of-concept study in experimental interstitial lung disease, we showed the potential of (18)F-AzaFol, an (18)F-labeled folic acid-based radiotracer, as a specific novel imaging tool for the visualization and monitoring of macrophage-driven lung diseases. (18)F-AzaFol binds to the folate receptor-beta (FRbeta) that is expressed on activated macrophages involved in inflammatory conditions. In a recent multicenter cancer trial, (18)F-AzaFol was successfully and safely applied (NCT03242993). It is supposed that the visualization of activated macrophage-related disease processes by folate radiotracer-based nuclear imaging can support clinical decision-making by identifying COVID-19 patients at risk of a severe disease progression with a potentially lethal outcome.
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