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10.3390/ijms21186582 http://scihub22266oqcxt.onion/10.3390/ijms21186582 32916818!7554980!32916818     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2020 ; 21 (18): ä Nephropedia Template TP {{tp|p=32916818|t=2020. mRNA Vaccine Era-Mechanisms, Drug Platform and Clinical Prospection |pdf=|usr=}}{{32916818}} gab.com Text mRNA Vaccine Era-Mechanisms, Drug Platform and Clinical Prospection JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=32916818 #FOAvip Messenger ribonucleic acid (mRNA)-based drugs, notably mRNA vaccines, have been widely proven as a promising treatment strategy in immune therapeutics. The extraordinary advantages associated with mRNA vaccines, including their high efficacy, a relatively low severity of side effects, and low attainment costs, have enabled them to become prevalent in pre-clinical and clinical trials against various infectious diseases and cancers. Recent technological advancements have alleviated some issues that hinder mRNA vaccine development, such as low efficiency that exist in both gene translation and in vivo deliveries. mRNA immunogenicity can also be greatly adjusted as a result of upgraded technologies. In this review, we have summarized details regarding the optimization of mRNA vaccines, and the underlying biological mechanisms of this form of vaccines. Applications of mRNA vaccines in some infectious diseases and cancers are introduced. It also includes our prospections for mRNA vaccine applications in diseases caused by bacterial pathogens, such as tuberculosis. At the same time, some suggestions for future mRNA vaccine development about storage methods, safety concerns, and personalized vaccine synthesis can be found in the context. Twit Text FOAVip mRNA Vaccine Era-Mechanisms, Drug Platform and Clinical Prospection ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=32916818 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32916818 #FOAvip English Wikipedia <ref>{{Cite pmid|32916818}}</ref> mRNA Vaccine Era-Mechanisms, Drug Platform and Clinical Prospection #MMPMID32916818 Xu S; Yang K; Li R; Zhang L Int J Mol Sci 2020[Sep]; 21 (18): ä PMID32916818show ga Messenger ribonucleic acid (mRNA)-based drugs, notably mRNA vaccines, have been widely proven as a promising treatment strategy in immune therapeutics. The extraordinary advantages associated with mRNA vaccines, including their high efficacy, a relatively low severity of side effects, and low attainment costs, have enabled them to become prevalent in pre-clinical and clinical trials against various infectious diseases and cancers. Recent technological advancements have alleviated some issues that hinder mRNA vaccine development, such as low efficiency that exist in both gene translation and in vivo deliveries. mRNA immunogenicity can also be greatly adjusted as a result of upgraded technologies. In this review, we have summarized details regarding the optimization of mRNA vaccines, and the underlying biological mechanisms of this form of vaccines. Applications of mRNA vaccines in some infectious diseases and cancers are introduced. It also includes our prospections for mRNA vaccine applications in diseases caused by bacterial pathogens, such as tuberculosis. At the same time, some suggestions for future mRNA vaccine development about storage methods, safety concerns, and personalized vaccine synthesis can be found in the context. |*Vaccines, Synthetic[MESH] |Drug Delivery Systems[MESH] |Immunogenicity, Vaccine[MESH] |RNA, Messenger/chemical synthesis/immunology[MESH]mRNA Vaccine Era-Mechanisms, Drug Platform and Clinical Prospection (epmc).pdf DeepDyve Pubget Overpricing