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10.1016/j.ejmech.2020.112783 http://scihub22266oqcxt.onion/10.1016/j.ejmech.2020.112783 32916311!7455853!32916311     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32916311&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Eur+J+Med+Chem 2020 ; 208 (?): 112783 Nephropedia Template TP {{tp|p=32916311|t=2020. Bioactive pyrrole-based compounds with target selectivity |pdf=|usr=}}{{32916311}} gab.com Text Bioactive pyrrole-based compounds with target selectivity JO: Eur J Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=32916311 #FOAvip The discovery of novel synthetic compounds with drug-like properties is an ongoing challenge in medicinal chemistry. Natural products have inspired the synthesis of compounds for pharmaceutical application, most of which are based on N-heterocyclic motifs. Among these, the pyrrole ring is one of the most explored heterocycles in drug discovery programs for several therapeutic areas, confirmed by the high number of pyrrole-based drugs reaching the market. In the present review, we focused on pyrrole and its hetero-fused derivatives with anticancer, antimicrobial, and antiviral activities, reported in the literature between 2015 and 2019, for which a specific target was identified, being responsible for their biological activity. It emerges that the powerful pharmaceutical and pharmacological features provided by the pyrrole nucleus as pharmacophore unit of many drugs are still recognized by medicinal chemists. Twit Text FOAVip Bioactive pyrrole-based compounds with target selectivity ????Eur J Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=32916311 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32916311 #FOAvip English Wikipedia <ref>{{Cite pmid|32916311}}</ref> Bioactive pyrrole-based compounds with target selectivity #MMPMID32916311 Li Petri G; Spano V; Spatola R; Holl R; Raimondi MV; Barraja P; Montalbano A Eur J Med Chem 2020[Dec]; 208 (?): 112783 PMID32916311show ga The discovery of novel synthetic compounds with drug-like properties is an ongoing challenge in medicinal chemistry. Natural products have inspired the synthesis of compounds for pharmaceutical application, most of which are based on N-heterocyclic motifs. Among these, the pyrrole ring is one of the most explored heterocycles in drug discovery programs for several therapeutic areas, confirmed by the high number of pyrrole-based drugs reaching the market. In the present review, we focused on pyrrole and its hetero-fused derivatives with anticancer, antimicrobial, and antiviral activities, reported in the literature between 2015 and 2019, for which a specific target was identified, being responsible for their biological activity. It emerges that the powerful pharmaceutical and pharmacological features provided by the pyrrole nucleus as pharmacophore unit of many drugs are still recognized by medicinal chemists. |*Molecular Targeted Therapy[MESH] |Anti-Infective Agents/chemistry/pharmacology[MESH] |Antineoplastic Agents/chemistry/pharmacology[MESH] |Antiviral Agents/chemistry/pharmacology[MESH] |Drug Design[MESH] |Humans[MESH]Bioactive pyrrole-based compounds with target selectivity (epmc).pdf DeepDyve Pubget Overpricing