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Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Cell+Syst 2020 ; 11 (4): 412-417.e2 Nephropedia Template TP
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Estimating the Binding of Sars-CoV-2 Peptides to HLA Class I in Human Subpopulations Using Artificial Neural Networks #MMPMID32916095
La Porta CAM; Zapperi S
Cell Syst 2020[Oct]; 11 (4): 412-417.e2 PMID32916095show ga
Epidemiological studies show that SARS-CoV-2 infection leads to severe symptoms only in a fraction of patients, but the determinants of individual susceptibility to the virus are still unknown. The major histocompatibility complex (MHC) class I exposes viral peptides in all nucleated cells and is involved in the susceptibility to many human diseases. Here, we use artificial neural networks to analyze the binding of SARS-CoV-2 peptides with polymorphic human MHC class I molecules. In this way, we identify two sets of haplotypes present in specific human populations: the first displays weak binding with SARS-CoV-2 peptides, while the second shows strong binding and T cell propensity. Our work offers a useful support to identify the individual susceptibility to COVID-19 and illustrates a mechanism underlying variations in the immune response to SARS-CoV-2. A record of this paper's transparent peer review process is included in the Supplemental Information.
|*Neural Networks, Computer[MESH]
|*Polymorphism, Genetic[MESH]
|Betacoronavirus/*immunology[MESH]
|Haplotypes[MESH]
|Histocompatibility Antigens Class I/chemistry/genetics/*immunology[MESH]