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10.1093/fampra/cmaa096

http://scihub22266oqcxt.onion/10.1093/fampra/cmaa096
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suck abstract from ncbi


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pmid32914857      Fam+Pract 2021 ; 38 (2): 154-159
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  • Community seroprevalence of COVID-19 in probable and possible cases at primary health care centres in Spain #MMPMID32914857
  • Montenegro P; Brotons C; Serrano J; Fernandez D; Garcia-Ramos C; Ichazo B; Lemaire J; Moral I; Wienese RP; Pitarch M; Puig M; Vilella MT; Sellares J
  • Fam Pract 2021[Mar]; 38 (2): 154-159 PMID32914857show ga
  • BACKGROUND: There is a scarcity of information about patients with mild or moderate symptoms during the coronavirus disease 2019 (COVID-19). This is especially true for those who attended and were followed up at primary care settings. OBJECTIVES: We aim to measure the seroprevalence of antibodies against SARS-CoV-2 infection in a community sample of possible cases and among probable cases followed in primary care. METHODS: We selected a random sample of 600 individuals stratified by age groups from a total population of 19 899 individuals from a community area in Barcelona. We also invited all the patients that had been followed by General Practitioners (GPs). For both populations, we used COVID-19 rapid lateral flow immunoassays, which qualitatively assess the presence of patient-generated Immunoglobulins G (IgG) and Immunoglobulin M (IgM). RESULTS: Three hundred and eleven asymptomatic individuals from the randomly selected sample participated in the study. The mean age was 43.7 years [standard deviation (SD) = 21.79] and 55% were women. Seventeen individuals were seropositive for IgM and/or IgG, resulting in an overall prevalence of 5.47% (95% confidence interval = 3.44-8.58). Six hundred and thirty-four symptomatic patients were followed up by GPs. The mean age was 46.97 years (SD = 20.05) and 57.73% were women. Of these, 244 patients (38.49%) were seropositive. Results of the multivariate logistic regression analysis showed that the odds ratio for a positive test was significantly increased in patients who had fever, ageusia and contact with a patient diagnosed with COVID-19. CONCLUSIONS: The seroprevalence of antibodies against SARS-CoV-2 among possible cases was lower than expected. Approximately, 40% of the symptomatic patients followed up by GPs during the peak months of the pandemic were positive.
  • |*COVID-19 Serological Testing[MESH]
  • |*Primary Health Care[MESH]
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |COVID-19/*diagnosis/*epidemiology[MESH]
  • |Child[MESH]
  • |Child, Preschool[MESH]
  • |Cross-Sectional Studies[MESH]
  • |Female[MESH]
  • |Follow-Up Studies[MESH]
  • |Humans[MESH]
  • |Infant[MESH]
  • |Logistic Models[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Prevalence[MESH]
  • |Prospective Studies[MESH]
  • |Seroepidemiologic Studies[MESH]
  • |Severity of Illness Index[MESH]
  • |Spain/epidemiology[MESH]


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