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10.1038/s41422-020-00412-6 http://scihub22266oqcxt.onion/10.1038/s41422-020-00412-6 32913304!7483052!32913304     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Res 2021 ; 31 (4): 415-432 Nephropedia Template TP {{tp|p=32913304|t=2021. Single-cell transcriptomic atlas of primate cardiopulmonary aging |pdf=|usr=}}{{32913304}} gab.com Text Single-cell transcriptomic atlas of primate cardiopulmonary aging JO: Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=32913304 #FOAvip Aging is a major risk factor for many diseases, especially in highly prevalent cardiopulmonary comorbidities and infectious diseases including Coronavirus Disease 2019 (COVID-19). Resolving cellular and molecular mechanisms associated with aging in higher mammals is therefore urgently needed. Here, we created young and old non-human primate single-nucleus/cell transcriptomic atlases of lung, heart and artery, the top tissues targeted by SARS-CoV-2. Analysis of cell type-specific aging-associated transcriptional changes revealed increased systemic inflammation and compromised virus defense as a hallmark of cardiopulmonary aging. With age, expression of the SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2) was increased in the pulmonary alveolar epithelial barrier, cardiomyocytes, and vascular endothelial cells. We found that interleukin 7 (IL7) accumulated in aged cardiopulmonary tissues and induced ACE2 expression in human vascular endothelial cells in an NF-kappaB-dependent manner. Furthermore, treatment with vitamin C blocked IL7-induced ACE2 expression. Altogether, our findings depict the first transcriptomic atlas of the aged primate cardiopulmonary system and provide vital insights into age-linked susceptibility to SARS-CoV-2, suggesting that geroprotective strategies may reduce COVID-19 severity in the elderly. Twit Text FOAVip Single-cell transcriptomic atlas of primate cardiopulmonary aging ????Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=32913304 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32913304 #FOAvip English Wikipedia <ref>{{Cite pmid|32913304}}</ref> Single-cell transcriptomic atlas of primate cardiopulmonary aging #MMPMID32913304 Ma S; Sun S; Li J; Fan Y; Qu J; Sun L; Wang S; Zhang Y; Yang S; Liu Z; Wu Z; Zhang S; Wang Q; Zheng A; Duo S; Yu Y; Belmonte JCI; Chan P; Zhou Q; Song M; Zhang W; Liu GH Cell Res 2021[Apr]; 31 (4): 415-432 PMID32913304show ga Aging is a major risk factor for many diseases, especially in highly prevalent cardiopulmonary comorbidities and infectious diseases including Coronavirus Disease 2019 (COVID-19). Resolving cellular and molecular mechanisms associated with aging in higher mammals is therefore urgently needed. Here, we created young and old non-human primate single-nucleus/cell transcriptomic atlases of lung, heart and artery, the top tissues targeted by SARS-CoV-2. Analysis of cell type-specific aging-associated transcriptional changes revealed increased systemic inflammation and compromised virus defense as a hallmark of cardiopulmonary aging. With age, expression of the SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2) was increased in the pulmonary alveolar epithelial barrier, cardiomyocytes, and vascular endothelial cells. We found that interleukin 7 (IL7) accumulated in aged cardiopulmonary tissues and induced ACE2 expression in human vascular endothelial cells in an NF-kappaB-dependent manner. Furthermore, treatment with vitamin C blocked IL7-induced ACE2 expression. Altogether, our findings depict the first transcriptomic atlas of the aged primate cardiopulmonary system and provide vital insights into age-linked susceptibility to SARS-CoV-2, suggesting that geroprotective strategies may reduce COVID-19 severity in the elderly. |*Aging[MESH] |*Transcriptome/drug effects[MESH] |Alveolar Epithelial Cells/cytology/metabolism/virology[MESH] |Angiotensin-Converting Enzyme 2/genetics/metabolism[MESH] |Animals[MESH] |Ascorbic Acid/pharmacology[MESH] |COVID-19/pathology/virology[MESH] |Cell Line[MESH] |Endothelial Cells/cytology/metabolism/virology[MESH] |Humans[MESH] |Interleukin-7/metabolism/pharmacology[MESH] |Macaca fascicularis[MESH] |Myocytes, Cardiac/cytology/metabolism/virology[MESH] |RNA-Seq[MESH] |SARS-CoV-2/isolation & purification/*physiology[MESH]Single-cell transcriptomic atlas of primate cardiopulmonary aging (epmc).pdf DeepDyve Pubget Overpricing