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10.1002/eji.202048838 http://scihub22266oqcxt.onion/10.1002/eji.202048838 32910469!ä!32910469 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Immunol 2020 ; 50 (9): 1283-1294 Nephropedia Template TP {{tp|p=32910469|t=2020. Expansion of plasmablasts and loss of memory B cells in peripheral blood from COVID-19 patients with pneumonia |pdf=|usr=}}{{32910469}} gab.com Text Expansion of plasmablasts and loss of memory B cells in peripheral blood from COVID-19 patients with pneumonia JO: Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32910469 #FOAvip Studies on the interactions between SARS-CoV-2 and humoral immunity are fundamental to elaborate effective therapies including vaccines. We used polychromatic flow cytometry, coupled with unsupervised data analysis and principal component analysis (PCA), to interrogate B cells in untreated patients with COVID-19 pneumonia. COVID-19 patients displayed normal plasma levels of the main immunoglobulin classes, of antibodies against common antigens or against antigens present in common vaccines. However, we found a decreased number of total and naive B cells, along with decreased percentages and numbers of memory switched and unswitched B cells. On the contrary, IgM(+) and IgM(-) plasmablasts were significantly increased. In vitro cell activation revealed that B lymphocytes showed a normal proliferation index and number of dividing cells per cycle. PCA indicated that B-cell number, naive and memory B cells but not plasmablasts clustered with patients who were discharged, while plasma IgM level, C-reactive protein, D-dimer, and SOFA score with those who died. In patients with pneumonia, the derangement of the B-cell compartment could be one of the causes of the immunological failure to control SARS-Cov2, have a relevant influence on several pathways, organs and systems, and must be considered to develop vaccine strategies. Twit Text FOAVip Expansion of plasmablasts and loss of memory B cells in peripheral blood from COVID-19 patients with pneumonia ????Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32910469 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32910469 #FOAvip English Wikipedia <ref>{{Cite pmid|32910469}}</ref> Expansion of plasmablasts and loss of memory B cells in peripheral blood from COVID-19 patients with pneumonia #MMPMID32910469 De Biasi S; Lo Tartaro D; Meschiari M; Gibellini L; Bellinazzi C; Borella R; Fidanza L; Mattioli M; Paolini A; Gozzi L; Jaacoub D; Faltoni M; Volpi S; Milic J; Sita M; Sarti M; Pucillo C; Girardis M; Guaraldi G; Mussini C; Cossarizza A Eur J Immunol 2020[Sep]; 50 (9): 1283-1294 PMID32910469show ga Studies on the interactions between SARS-CoV-2 and humoral immunity are fundamental to elaborate effective therapies including vaccines. We used polychromatic flow cytometry, coupled with unsupervised data analysis and principal component analysis (PCA), to interrogate B cells in untreated patients with COVID-19 pneumonia. COVID-19 patients displayed normal plasma levels of the main immunoglobulin classes, of antibodies against common antigens or against antigens present in common vaccines. However, we found a decreased number of total and naive B cells, along with decreased percentages and numbers of memory switched and unswitched B cells. On the contrary, IgM(+) and IgM(-) plasmablasts were significantly increased. In vitro cell activation revealed that B lymphocytes showed a normal proliferation index and number of dividing cells per cycle. PCA indicated that B-cell number, naive and memory B cells but not plasmablasts clustered with patients who were discharged, while plasma IgM level, C-reactive protein, D-dimer, and SOFA score with those who died. In patients with pneumonia, the derangement of the B-cell compartment could be one of the causes of the immunological failure to control SARS-Cov2, have a relevant influence on several pathways, organs and systems, and must be considered to develop vaccine strategies. |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Antibodies, Viral/*blood/classification[MESH] |B-Lymphocytes/*immunology/virology[MESH] |Betacoronavirus/immunology/*pathogenicity[MESH] |C-Reactive Protein/immunology[MESH] |COVID-19[MESH] |Case-Control Studies[MESH] |Cell Proliferation[MESH] |Coronavirus Infections/*immunology/mortality/pathology/virology[MESH] |Cross-Sectional Studies[MESH] |Cytokines/genetics/immunology[MESH] |Female[MESH] |Fibrin Fibrinogen Degradation Products/immunology[MESH] |Humans[MESH] |Immunity, Humoral[MESH] |Immunoglobulin Isotypes/*blood[MESH] |Immunologic Memory[MESH] |Lung/*immunology/pathology/virology[MESH] |Lymphocyte Activation[MESH] |Lymphocyte Count[MESH] |Male[MESH] |Middle Aged[MESH] |Organ Dysfunction Scores[MESH] |Pandemics[MESH] |Pneumonia, Viral/*immunology/mortality/pathology/virology[MESH] |Primary Cell Culture[MESH] |SARS-CoV-2[MESH] |Severity of Illness Index[MESH]Expansion of plasmablasts and loss of memory B cells in peripheral blo(epmc).pdf DeepDyve Pubget Overpricing