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10.1093/infdis/jiaa581 http://scihub22266oqcxt.onion/10.1093/infdis/jiaa581 32910175!7499592!32910175     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Infect+Dis 2020 ; 222 (12): 1974-1984 Nephropedia Template TP {{tp|p=32910175|t=2020. SARS-CoV-2 Antibody Avidity Responses in COVID-19 Patients and Convalescent Plasma Donors |pdf=|usr=}}{{32910175}} gab.com Text SARS-CoV-2 Antibody Avidity Responses in COVID-19 Patients and Convalescent Plasma Donors JO: J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=32910175 #FOAvip BACKGROUND: Convalescent plasma therapy is a leading treatment for conferring temporary immunity to COVID-19-susceptible individuals or for use as post-exposure prophylaxis. However, not all recovered patients develop adequate antibody titers for donation and the relationship between avidity and neutralizing titers is currently not well understood. METHODS: SARS-CoV-2 anti-spike and anti-nucleocapsid IgG titers and avidity were measured in a longitudinal cohort of COVID-19 hospitalized patients (n = 16 individuals) and a cross-sectional sample of convalescent plasma donors (n = 130). Epidemiologic correlates of avidity were examined in donors by linear regression. The association of avidity and a high neutralizing titer (NT) were also assessed in donors using modified Poisson regression. RESULTS: Antibody avidity increased over duration of infection and remained elevated. In convalescent plasma donors, higher levels of anti-spike avidity were associated with older age, male sex, and hospitalization. Higher NTs had a stronger positive correlation with anti-spike IgG avidity (Spearman rho = 0.386; P < .001) than with anti-nucleocapsid IgG avidity (Spearman rho = 0.211; P = .026). Increasing levels of anti-spike IgG avidity were associated with high NT (>/=160) (adjusted prevalence ratio = 1.58 [95% confidence interval = 1.19-2.12]), independent of age, sex, and hospitalization. CONCLUSIONS: SARS-CoV-2 antibody avidity correlated with duration of infection and higher neutralizing titers, suggesting a potential alternative screening parameter for identifying optimal convalescent plasma donors. Twit Text FOAVip SARS-CoV-2 Antibody Avidity Responses in COVID-19 Patients and Convalescent Plasma Donors ????J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=32910175 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32910175 #FOAvip English Wikipedia <ref>{{Cite pmid|32910175}}</ref> SARS-CoV-2 Antibody Avidity Responses in COVID-19 Patients and Convalescent Plasma Donors #MMPMID32910175 Benner SE; Patel EU; Laeyendecker O; Pekosz A; Littlefield K; Eby Y; Fernandez RE; Miller J; Kirby CS; Keruly M; Klock E; Baker OR; Schmidt HA; Shrestha R; Burgess I; Bonny TS; Clarke W; Caturegli P; Sullivan D; Shoham S; Quinn TC; Bloch EM; Casadevall A; Tobian AAR; Redd AD J Infect Dis 2020[Nov]; 222 (12): 1974-1984 PMID32910175show ga BACKGROUND: Convalescent plasma therapy is a leading treatment for conferring temporary immunity to COVID-19-susceptible individuals or for use as post-exposure prophylaxis. However, not all recovered patients develop adequate antibody titers for donation and the relationship between avidity and neutralizing titers is currently not well understood. METHODS: SARS-CoV-2 anti-spike and anti-nucleocapsid IgG titers and avidity were measured in a longitudinal cohort of COVID-19 hospitalized patients (n = 16 individuals) and a cross-sectional sample of convalescent plasma donors (n = 130). Epidemiologic correlates of avidity were examined in donors by linear regression. The association of avidity and a high neutralizing titer (NT) were also assessed in donors using modified Poisson regression. RESULTS: Antibody avidity increased over duration of infection and remained elevated. In convalescent plasma donors, higher levels of anti-spike avidity were associated with older age, male sex, and hospitalization. Higher NTs had a stronger positive correlation with anti-spike IgG avidity (Spearman rho = 0.386; P < .001) than with anti-nucleocapsid IgG avidity (Spearman rho = 0.211; P = .026). Increasing levels of anti-spike IgG avidity were associated with high NT (>/=160) (adjusted prevalence ratio = 1.58 [95% confidence interval = 1.19-2.12]), independent of age, sex, and hospitalization. CONCLUSIONS: SARS-CoV-2 antibody avidity correlated with duration of infection and higher neutralizing titers, suggesting a potential alternative screening parameter for identifying optimal convalescent plasma donors. |*Antibody Affinity[MESH] |*SARS-CoV-2[MESH] |Adolescent[MESH] |Adult[MESH] |Antibodies, Neutralizing/*administration & dosage/blood[MESH] |Antibodies, Viral/*administration & dosage/blood[MESH] |Blood Donors[MESH] |COVID-19 Serotherapy[MESH] |COVID-19/*therapy[MESH] |Cohort Studies[MESH] |Cross-Sectional Studies[MESH] |Female[MESH] |Humans[MESH] |Immunization, Passive[MESH] |Immunoglobulin G/*administration & dosage/blood[MESH] |Linear Models[MESH] |Male[MESH] |Middle Aged[MESH] |Spike Glycoprotein, Coronavirus/immunology[MESH]SARS-CoV-2 Antibody Avidity Responses in COVID-19 Patients and Convale(epmc).pdf DeepDyve Pubget Overpricing