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10.1101/2020.08.29.20182899 http://scihub22266oqcxt.onion/10.1101/2020.08.29.20182899 32909006!7480058!32909006     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       medRxiv 2020 ; ä (ä): ä Nephropedia Template TP {{tp|p=32909006|t=2020. Cytotoxic lymphocytes are dysregulated in multisystem inflammatory syndrome in children |pdf=|usr=}}{{32909006}} gab.com Text Cytotoxic lymphocytes are dysregulated in multisystem inflammatory syndrome in children JO: medRxiv http://www.kidney.de/pget.php?&tw=1&pmid=32909006 #FOAvip Multisystem inflammatory syndrome in children (MIS-C) presents with fever, inflammation and multiple organ involvement in individuals under 21 years following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. To identify genes, pathways and cell types driving MIS-C, we sequenced the blood transcriptomes of MIS-C cases, pediatric cases of coronavirus disease 2019, and healthy controls. We define a MIS-C transcriptional signature partially shared with the transcriptional response to SARS-CoV-2 infection and with the signature of Kawasaki disease, a clinically similar condition. By projecting the MIS-C signature onto a co-expression network, we identified disease gene modules and found genes downregulated in MIS-C clustered in a module enriched for the transcriptional signatures of exhausted CD8 (+) T-cells and CD56 (dim) CD57 (+) NK cells. Bayesian network analyses revealed nine key regulators of this module, including TBX21 , a central coordinator of exhausted CD8 (+) T-cell differentiation. Together, these findings suggest dysregulated cytotoxic lymphocyte response to SARS-Cov-2 infection in MIS-C. Twit Text FOAVip Cytotoxic lymphocytes are dysregulated in multisystem inflammatory syndrome in children ????medRxiv http://www.kidney.de/pget.php?&tw=1&pmid=32909006 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32909006 #FOAvip English Wikipedia <ref>{{Cite pmid|32909006}}</ref> Cytotoxic lymphocytes are dysregulated in multisystem inflammatory syndrome in children #MMPMID32909006 Beckmann ND; Comella PH; Cheng E; Lepow L; Beckmann AG; Mouskas K; Simons NW; Hoffman GE; Francoeur NJ; Del Valle DM; Kang G; Moya E; Wilkins L; Le Berichel J; Chang C; Marvin R; Calorossi S; Lansky A; Walker L; Yi N; Yu A; Hartnett M; Eaton M; Hatem S; Jamal H; Akyatan A; Tabachnikova A; Liharska LE; Cotter L; Fennessey B; Vaid A; Barturen G; Tyler SR; Shah H; Wang YC; Sridhar SH; Soto J; Bose S; Madrid K; Ellis E; Merzier E; Vlachos K; Fishman N; Tin M; Smith M; Xie H; Patel M; Argueta K; Harris J; Karekar N; Batchelor C; Lacunza J; Yishak M; Tuballes K; Scott L; Kumar A; Jaladanki S; Thompson R; Clark E; Losic B; Zhu J; Wang W; Kasarskis A; Glicksberg BS; Nadkarni G; Bogunovic D; Elaiho C; Gangadharan S; Ofori-Amanfo G; Alesso-Carra K; Onel K; Wilson KM; Argmann C; Alarcon-Riquelme ME; Marron TU; Rahman A; Kim-Schulze S; Gnjatic S; Gelb BD; Merad M; Sebra R; Schadt EE; Charney AW medRxiv 2020[Sep]; ä (ä): ä PMID32909006show ga Multisystem inflammatory syndrome in children (MIS-C) presents with fever, inflammation and multiple organ involvement in individuals under 21 years following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. To identify genes, pathways and cell types driving MIS-C, we sequenced the blood transcriptomes of MIS-C cases, pediatric cases of coronavirus disease 2019, and healthy controls. We define a MIS-C transcriptional signature partially shared with the transcriptional response to SARS-CoV-2 infection and with the signature of Kawasaki disease, a clinically similar condition. By projecting the MIS-C signature onto a co-expression network, we identified disease gene modules and found genes downregulated in MIS-C clustered in a module enriched for the transcriptional signatures of exhausted CD8 (+) T-cells and CD56 (dim) CD57 (+) NK cells. Bayesian network analyses revealed nine key regulators of this module, including TBX21 , a central coordinator of exhausted CD8 (+) T-cell differentiation. Together, these findings suggest dysregulated cytotoxic lymphocyte response to SARS-Cov-2 infection in MIS-C. äCytotoxic lymphocytes are dysregulated in multisystem inflammatory syn(epmc).pdf DeepDyve Pubget Overpricing