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10.3390/ijerph17186493

http://scihub22266oqcxt.onion/10.3390/ijerph17186493
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32906596!7558531!32906596
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suck abstract from ncbi


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pmid32906596      Int+J+Environ+Res+Public+Health 2020 ; 17 (18): ä
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  • The Light and Shadow of Rapid Serological Tests for SARS-CoV-2 Infection: Results from a Study in a Large Emergency Department #MMPMID32906596
  • Loconsole D; Centrone F; Morcavallo C; Campanella S; Sallustio A; Quarto M; Procacci V; Chironna M
  • Int J Environ Res Public Health 2020[Sep]; 17 (18): ä PMID32906596show ga
  • A critical point in the management of the SARS-CoV-2 pandemic is the need to promptly identify the greatest number of infected people and to implement strict public health measures. In this study, the performance of a rapid serological test in a clinical setting was evaluated. Samples from 819 consecutive patients (with or without respiratory symptoms) admitted to a large Emergency Department were tested between 23 March and 21 April 2020. Patient samples were tested in a real-time PCR assay and a serological assay. In total, 148/819 patients (18.1%) tested positive for SARS-CoV-2 by real-time PCR. The serological test revealed that 70/819 patients (8.5%) had anti-SARS-CoV-2 IgM and/or IgG. The prevalence of anti-SARS-CoV-2 antibodies was significantly higher in patients with respiratory symptoms lasting for >7 days than in those with respiratory symptoms lasting for 0-7 days (p < 0.001). The serological assay had an overall sensitivity of 35.1% and an overall specificity of 97.3%. A high negative predictive value (96.7%) was reported for patients without respiratory symptoms. The results confirm that rapid serological assays alone are not sufficient for diagnosis of SARS-CoV-2 infection but can be incorporated into large-scale screening programs during periods in which the virus circulation is low.
  • |*Pandemics[MESH]
  • |Antibodies, Viral/*blood[MESH]
  • |Betacoronavirus/*isolation & purification[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Testing[MESH]
  • |Clinical Laboratory Techniques/*methods[MESH]
  • |Coronavirus Infections/*diagnosis/epidemiology[MESH]
  • |Emergency Service, Hospital/*statistics & numerical data[MESH]
  • |Humans[MESH]
  • |Immunoglobulin G/blood[MESH]
  • |Pneumonia, Viral/*diagnosis/epidemiology[MESH]
  • |Real-Time Polymerase Chain Reaction[MESH]
  • |SARS-CoV-2[MESH]
  • |Sensitivity and Specificity[MESH]


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  • suck abstract from ncbi

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