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High Seroprevalence of Anti-SARS-CoV-2 Antibodies in Chelsea, Massachusetts #MMPMID32906151
Naranbhai V; Chang CC; Beltran WFG; Miller TE; Astudillo MG; Villalba JA; Yang D; Gelfand J; Bernstein BE; Feldman J; Hauser BM; Caradonna TM; Alter G; Murali MR; Jasrasaria R; Quinlan J; Xerras DC; Betancourt JR; Louis DN; Schmidt AG; Lennerz J; Poznansky MC; Iafrate AJ
J Infect Dis 2020[Nov]; 222 (12): 1955-1959 PMID32906151show ga
SARS-CoV-2 antibody testing allows quantitative determination of disease prevalence, which is especially important in high-risk communities. We performed anonymized convenience sampling of 200 currently asymptomatic residents of Chelsea, the epicenter of COVID-19 illness in Massachusetts, by BioMedomics SARS-CoV-2 combined IgM-IgG point-of-care lateral flow immunoassay. The seroprevalence was 31.5% (17.5% IgM+IgG+, 9.0% IgM+IgG-, and 5.0% IgM-IgG+). Of the 200 participants, 50.5% reported no symptoms in the preceding 4 weeks, of which 24.8% (25/101) were seropositive, and 60% of these were IgM+IgG-. These data are the highest seroprevalence rates observed to date and highlight the significant burden of asymptomatic infection.