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Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 PLoS+One 2020 ; 15 (9): e0238089 Nephropedia Template TP
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Identification of immunodominant linear epitopes from SARS-CoV-2 patient plasma #MMPMID32903266
Farrera-Soler L; Daguer JP; Barluenga S; Vadas O; Cohen P; Pagano S; Yerly S; Kaiser L; Vuilleumier N; Winssinger N
PLoS One 2020[]; 15 (9): e0238089 PMID32903266show ga
A novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) is the source of a current pandemic (COVID-19) with devastating consequences in public health and economic stability. Using a peptide array to map the antibody response of plasma from healing patients (12) and heathy patients (6), we identified three immunodominant linear epitopes, two of which correspond to key proteolytic sites on the spike protein (S1/S2 and S2') known to be critical for cellular entry. We show biochemical evidence that plasma positive for the epitope adjacent to the S1/S2 cleavage site inhibits furin-mediated proteolysis of spike.