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10.1177/1753425920954281 http://scihub22266oqcxt.onion/10.1177/1753425920954281 32903111!7882805!32903111     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Innate+Immun 2021 ; 27 (2): 109-117 Nephropedia Template TP {{tp|p=32903111|t=2021. Immune response and blood-brain barrier dysfunction during viral neuroinvasion |pdf=|usr=}}{{32903111}} gab.com Text Immune response and blood-brain barrier dysfunction during viral neuroinvasion JO: Innate Immun http://www.kidney.de/pget.php?&tw=1&pmid=32903111 #FOAvip The blood-brain barrier (BBB), which protects the CNS from pathogens, is composed of specialized brain microvascular endothelial cells (BMECs) joined by tight junctions and ensheathed by pericytes and astrocyte endfeet. The stability of the BBB structure and function is of great significance for the maintenance of brain homeostasis. When a neurotropic virus invades the CNS via a hematogenous or non-hematogenous route, it may cause structural and functional disorders of the BBB, and also activate the BBB anti-inflammatory or pro-inflammatory innate immune response. This article focuses on the structural and functional changes that occur in the three main components of the BBB (endothelial cells, astrocytes, and pericytes) in response to infection with neurotropic viruses transmitted by hematogenous routes, and also briefly describes the supportive effect of three cells on the BBB under normal physiological conditions. For example, all three types of cells express several PRRs, which can quickly sense the virus and make corresponding immune responses. The pro-inflammatory immune response will exacerbate the destruction of the BBB, while the anti-inflammatory immune response, based on type I IFN, consolidates the stability of the BBB. Exploring the details of the interaction between the host and the pathogen at the BBB during neurotropic virus infection will help to propose new treatments for viral encephalitis. Enhancing the defense function of the BBB, maintaining the integrity of the BBB, and suppressing the pro-inflammatory immune response of the BBB provide more ideas for limiting the neuroinvasion of neurotropic viruses. In the future, these new treatments are expected to cooperate with traditional antiviral methods to improve the therapeutic effect of viral encephalitis. Twit Text FOAVip Immune response and blood-brain barrier dysfunction during viral neuroinvasion ????Innate Immun http://www.kidney.de/pget.php?&tw=1&pmid=32903111 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32903111 #FOAvip English Wikipedia <ref>{{Cite pmid|32903111}}</ref> Immune response and blood-brain barrier dysfunction during viral neuroinvasion #MMPMID32903111 Chen Z; Li G Innate Immun 2021[Feb]; 27 (2): 109-117 PMID32903111show ga The blood-brain barrier (BBB), which protects the CNS from pathogens, is composed of specialized brain microvascular endothelial cells (BMECs) joined by tight junctions and ensheathed by pericytes and astrocyte endfeet. The stability of the BBB structure and function is of great significance for the maintenance of brain homeostasis. When a neurotropic virus invades the CNS via a hematogenous or non-hematogenous route, it may cause structural and functional disorders of the BBB, and also activate the BBB anti-inflammatory or pro-inflammatory innate immune response. This article focuses on the structural and functional changes that occur in the three main components of the BBB (endothelial cells, astrocytes, and pericytes) in response to infection with neurotropic viruses transmitted by hematogenous routes, and also briefly describes the supportive effect of three cells on the BBB under normal physiological conditions. For example, all three types of cells express several PRRs, which can quickly sense the virus and make corresponding immune responses. The pro-inflammatory immune response will exacerbate the destruction of the BBB, while the anti-inflammatory immune response, based on type I IFN, consolidates the stability of the BBB. Exploring the details of the interaction between the host and the pathogen at the BBB during neurotropic virus infection will help to propose new treatments for viral encephalitis. Enhancing the defense function of the BBB, maintaining the integrity of the BBB, and suppressing the pro-inflammatory immune response of the BBB provide more ideas for limiting the neuroinvasion of neurotropic viruses. In the future, these new treatments are expected to cooperate with traditional antiviral methods to improve the therapeutic effect of viral encephalitis. |Animals[MESH] |Blood-Brain Barrier/*physiology[MESH] |COVID-19/*immunology[MESH] |Endothelial Cells/*physiology/virology[MESH] |Humans[MESH] |Immunity, Innate[MESH] |Interferons/metabolism[MESH] |Nervous System/*virology[MESH] |SARS-CoV-2/*physiology[MESH]Immune response and blood-brain barrier dysfunction during viral neuro(epmc).pdf DeepDyve Pubget Overpricing