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10.1136/medethics-2020-106793 http://scihub22266oqcxt.onion/10.1136/medethics-2020-106793 32900846!ä!32900846 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Med+Ethics 2020 ; 46 (12): 813-814 Nephropedia Template TP {{tp|p=32900846|t=2020. Uncertainty, error and informed consent to challenge trials of COVID-19 vaccines: response to Steel et al |pdf=|usr=}}{{32900846}} gab.com Text Uncertainty, error and informed consent to challenge trials of COVID-19 vaccines: response to Steel et al JO: J Med Ethics http://www.kidney.de/pget.php?&tw=1&pmid=32900846 #FOAvip In a recent article, Steel, Buchak and Eyal (SBE) argue that current levels of uncertainty do not present a good reason to bar controlled human infection (CHI) trials of COVID-19 vaccines from proceeding. We argue that their argumentation for this conclusion is flawed. SBE are mistaken about the effects which different forms of ignorance have on participants' ability to provide valid informed consent. Decision-makers considering whether to allow such trials, we argue, must ultimately consider the likelihood that consent to participation in such trials under current conditions would be valid, and whether this likelihood is high enough to permit such trials. This is a question that SBE completely ignore. We conclude that there indeed are valid concerns about conducting CHI trials given the current state of knowledge about COVID-19, concerns which SBE fail to address. Twit Text FOAVip Uncertainty, error and informed consent to challenge trials of COVID-19 vaccines: response to Steel et al ????J Med Ethics http://www.kidney.de/pget.php?&tw=1&pmid=32900846 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32900846 #FOAvip English Wikipedia <ref>{{Cite pmid|32900846}}</ref> Uncertainty, error and informed consent to challenge trials of COVID-19 vaccines: response to Steel et al #MMPMID32900846 Keren A; Lev O J Med Ethics 2020[Dec]; 46 (12): 813-814 PMID32900846show ga In a recent article, Steel, Buchak and Eyal (SBE) argue that current levels of uncertainty do not present a good reason to bar controlled human infection (CHI) trials of COVID-19 vaccines from proceeding. We argue that their argumentation for this conclusion is flawed. SBE are mistaken about the effects which different forms of ignorance have on participants' ability to provide valid informed consent. Decision-makers considering whether to allow such trials, we argue, must ultimately consider the likelihood that consent to participation in such trials under current conditions would be valid, and whether this likelihood is high enough to permit such trials. This is a question that SBE completely ignore. We conclude that there indeed are valid concerns about conducting CHI trials given the current state of knowledge about COVID-19, concerns which SBE fail to address. |*COVID-19 Vaccines[MESH] |*COVID-19/prevention & control[MESH] |*Informed Consent[MESH] |Clinical Trials as Topic[MESH] |Humans[MESH] |Pandemics[MESH] |SARS-CoV-2[MESH]Uncertainty, error and informed consent to challenge trials of COVID-1(epmc).pdf DeepDyve Pubget Overpricing