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10.3390/v12090987 http://scihub22266oqcxt.onion/10.3390/v12090987 32899480!7552029!32899480     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32899480&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Viruses 2020 ; 12 (9): ? Nephropedia Template TP {{tp|p=32899480|t=2020. Attenuated Influenza Virions Expressing the SARS-CoV-2 Receptor-Binding Domain Induce Neutralizing Antibodies in Mice |pdf=|usr=}}{{32899480}} gab.com Text Attenuated Influenza Virions Expressing the SARS-CoV-2 Receptor-Binding Domain Induce Neutralizing Antibodies in Mice JO: Viruses http://www.kidney.de/pget.php?&tw=1&pmid=32899480 #FOAvip An effective vaccine is essential for controlling the spread of the SARS-CoV-2 virus. Here, we describe an influenza virus-based vaccine for SARS-CoV-2. We incorporated a membrane-anchored form of the SARS-CoV-2 spike receptor binding domain (RBD) in place of the neuraminidase (NA) coding sequence in an influenza virus also possessing a mutation that reduces the affinity of hemagglutinin for its sialic acid receptor. The resulting DeltaNA(RBD)-Flu virus can be generated by reverse genetics and grown to high titers in cell culture. A single-dose intranasal inoculation of mice with DeltaNA(RBD)-Flu elicits serum neutralizing antibody titers against SAR-CoV-2 comparable to those observed in humans following natural infection (~1:200). Furthermore, DeltaNA(RBD)-Flu itself causes no apparent disease in mice. It might be possible to produce a vaccine similar to DeltaNA(RBD)-Flu at scale by leveraging existing platforms for the production of influenza vaccines. Twit Text FOAVip Attenuated Influenza Virions Expressing the SARS-CoV-2 Receptor-Binding Domain Induce Neutralizing Antibodies in Mice ????Viruses http://www.kidney.de/pget.php?&tw=1&pmid=32899480 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32899480 #FOAvip English Wikipedia <ref>{{Cite pmid|32899480}}</ref> Attenuated Influenza Virions Expressing the SARS-CoV-2 Receptor-Binding Domain Induce Neutralizing Antibodies in Mice #MMPMID32899480 Loes AN; Gentles LE; Greaney AJ; Crawford KHD; Bloom JD Viruses 2020[Sep]; 12 (9): ? PMID32899480show ga An effective vaccine is essential for controlling the spread of the SARS-CoV-2 virus. Here, we describe an influenza virus-based vaccine for SARS-CoV-2. We incorporated a membrane-anchored form of the SARS-CoV-2 spike receptor binding domain (RBD) in place of the neuraminidase (NA) coding sequence in an influenza virus also possessing a mutation that reduces the affinity of hemagglutinin for its sialic acid receptor. The resulting DeltaNA(RBD)-Flu virus can be generated by reverse genetics and grown to high titers in cell culture. A single-dose intranasal inoculation of mice with DeltaNA(RBD)-Flu elicits serum neutralizing antibody titers against SAR-CoV-2 comparable to those observed in humans following natural infection (~1:200). Furthermore, DeltaNA(RBD)-Flu itself causes no apparent disease in mice. It might be possible to produce a vaccine similar to DeltaNA(RBD)-Flu at scale by leveraging existing platforms for the production of influenza vaccines. |*COVID-19 Vaccines/administration & dosage/genetics[MESH] |*COVID-19/prevention & control[MESH] |*Pandemics[MESH] |Administration, Intranasal[MESH] |Animals[MESH] |Antibodies, Neutralizing[MESH] |Antibodies, Viral[MESH] |Coronavirus Infections[MESH] |Fertility[MESH] |Influenza A virus/genetics[MESH] |Mice[MESH] |SARS-CoV-2/genetics[MESH] |Spike Glycoprotein, Coronavirus/genetics[MESH]Attenuated Influenza Virions Expressing the SARS-CoV-2 Receptor-Bindin(epmc).pdf DeepDyve Pubget Overpricing