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10.3390/cells9092028 http://scihub22266oqcxt.onion/10.3390/cells9092028 32899180!7565710!32899180     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cells 2020 ; 9 (9): ä Nephropedia Template TP {{tp|p=32899180|t=2020. Membrane Transporters for Amino Acids as Players of Cancer Metabolic Rewiring |pdf=|usr=}}{{32899180}} gab.com Text Membrane Transporters for Amino Acids as Players of Cancer Metabolic Rewiring JO: Cells http://www.kidney.de/pget.php?&tw=1&pmid=32899180 #FOAvip Cancer cells perform a metabolic rewiring to sustain an increased growth rate and compensate for the redox stress caused by augmented energy metabolism. The metabolic changes are not the same in all cancers. Some features, however, are considered hallmarks of this disease. As an example, all cancer cells rewire the amino acid metabolism for fulfilling both the energy demand and the changed signaling routes. In these altered conditions, some amino acids are more frequently used than others. In any case, the prerequisite for amino acid utilization is the presence of specific transporters in the cell membrane that can guarantee the absorption and the traffic of amino acids among tissues. Tumor cells preferentially use some of these transporters for satisfying their needs. The evidence for this phenomenon is the over-expression of selected transporters, associated with specific cancer types. The knowledge of the link between the over-expression and the metabolic rewiring is crucial for understanding the molecular mechanism of reprogramming in cancer cells. The continuous growth of information on structure-function relationships and the regulation of transporters will open novel perspectives in the fight against human cancers. Twit Text FOAVip Membrane Transporters for Amino Acids as Players of Cancer Metabolic Rewiring ????Cells http://www.kidney.de/pget.php?&tw=1&pmid=32899180 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32899180 #FOAvip English Wikipedia <ref>{{Cite pmid|32899180}}</ref> Membrane Transporters for Amino Acids as Players of Cancer Metabolic Rewiring #MMPMID32899180 Scalise M; Console L; Rovella F; Galluccio M; Pochini L; Indiveri C Cells 2020[Sep]; 9 (9): ä PMID32899180show ga Cancer cells perform a metabolic rewiring to sustain an increased growth rate and compensate for the redox stress caused by augmented energy metabolism. The metabolic changes are not the same in all cancers. Some features, however, are considered hallmarks of this disease. As an example, all cancer cells rewire the amino acid metabolism for fulfilling both the energy demand and the changed signaling routes. In these altered conditions, some amino acids are more frequently used than others. In any case, the prerequisite for amino acid utilization is the presence of specific transporters in the cell membrane that can guarantee the absorption and the traffic of amino acids among tissues. Tumor cells preferentially use some of these transporters for satisfying their needs. The evidence for this phenomenon is the over-expression of selected transporters, associated with specific cancer types. The knowledge of the link between the over-expression and the metabolic rewiring is crucial for understanding the molecular mechanism of reprogramming in cancer cells. The continuous growth of information on structure-function relationships and the regulation of transporters will open novel perspectives in the fight against human cancers. |Amino Acids/*metabolism[MESH] |Cell Line, Tumor[MESH] |Energy Metabolism/*genetics[MESH] |Humans[MESH] |Membrane Transport Proteins/*metabolism[MESH]Membrane Transporters for Amino Acids as Players of Cancer Metabolic R(epmc).pdf DeepDyve Pubget Overpricing