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10.1111/pai.13361

http://scihub22266oqcxt.onion/10.1111/pai.13361
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32897642!7887110!32897642
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suck abstract from ncbi


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pmid32897642      Pediatr+Allergy+Immunol 2021 ; 32 (1): 17-22
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  • The potential threat of multisystem inflammatory syndrome in children during the COVID-19 pandemic #MMPMID32897642
  • Rothan HA; Byrareddy SN
  • Pediatr Allergy Immunol 2021[Jan]; 32 (1): 17-22 PMID32897642show ga
  • Multisystem inflammatory syndrome in children (MIS-C) during the COVID-19 pandemic raised a global alert from the Centers for Disease Control and Prevention's Health Alert Network. The main manifestations of MIS-C (also known as pediatric MIS (PMIS)) in the setting of a severe inflammatory state include fever, diarrhea, shock, and variable presence of rash, conjunctivitis, extremity edema, and mucous membrane changes. In some cases, these symptoms progressed to multi-organ failure. The low percentage of children with asymptomatic cases compared with mild illness and moderate illness could be correlated with the rare cases of MIS-C. One potential explanation for the progression to severe MIS-C disease despite the presence of readily detectable anti-SARS-CoV-2 antibodies could be due to the potential role of antibody-dependent enhancement (ADE). We reason that the incidence of the ADE phenomenon whereby the pathogen-specific antibodies can promote pathology should be considered in vaccine development against SARS-CoV-2.
  • |Adolescent[MESH]
  • |Antibodies, Viral/immunology[MESH]
  • |Antibody-Dependent Enhancement/immunology[MESH]
  • |COVID-19/*epidemiology/immunology[MESH]
  • |Child[MESH]
  • |Child, Preschool[MESH]
  • |Conjunctivitis/epidemiology[MESH]
  • |Diarrhea/epidemiology[MESH]
  • |Exanthema/epidemiology[MESH]
  • |Humans[MESH]
  • |Infant[MESH]
  • |Macrophage Activation/immunology[MESH]
  • |Pandemics[MESH]
  • |SARS-CoV-2/immunology[MESH]
  • |Severity of Illness Index[MESH]
  • |Systemic Inflammatory Response Syndrome/*epidemiology/immunology[MESH]


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