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10.1016/j.ajic.2020.08.022

http://scihub22266oqcxt.onion/10.1016/j.ajic.2020.08.022
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32896604!7473342!32896604
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suck abstract from ncbi


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pmid32896604      Am+J+Infect+Control 2021 ; 49 (3): 299-301
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  • Effectiveness of 222-nm ultraviolet light on disinfecting SARS-CoV-2 surface contamination #MMPMID32896604
  • Kitagawa H; Nomura T; Nazmul T; Omori K; Shigemoto N; Sakaguchi T; Ohge H
  • Am J Infect Control 2021[Mar]; 49 (3): 299-301 PMID32896604show ga
  • BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), has emerged as a serious threat to human health worldwide. Efficient disinfection of surfaces contaminated with SARS-CoV-2 may help prevent its spread. This study aimed to investigate the in vitro efficacy of 222-nm far-ultraviolet light (UVC) on the disinfection of SARS-CoV-2 surface contamination. METHODS: We investigated the titer of SARS-CoV-2 after UV irradiation (0.1 mW/cm(2)) at 222 nm for 10-300 seconds using the 50% tissue culture infectious dose (TCID(50)). In addition, we used quantitative reverse transcription polymerase chain reaction to quantify SARS-CoV-2 RNA under the same conditions. RESULTS: One and 3 mJ/cm(2) of 222-nm UVC irradiation (0.1 mW/cm(2) for 10 and 30 seconds) resulted in 88.5 and 99.7% reduction of viable SARS-CoV-2 based on the TCID(50) assay, respectively. In contrast, the copy number of SARS-CoV-2 RNA did not change after UVC irradiation even after a 5-minute irradiation. CONCLUSIONS: This study shows the efficacy of 222-nm UVC irradiation against SARS-CoV-2 contamination in an in vitro experiment. Further evaluation of the safety and efficacy of 222-nm UVC irradiation in reducing the contamination of real-world surfaces and the potential transmission of SARS-CoV-2 is needed.
  • |*Ultraviolet Rays[MESH]
  • |COVID-19/prevention & control/virology[MESH]
  • |Decontamination/*methods[MESH]
  • |Disinfection/*methods[MESH]
  • |Humans[MESH]
  • |RNA, Viral/*radiation effects[MESH]


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