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10.1093/clinchem/hvaa211

http://scihub22266oqcxt.onion/10.1093/clinchem/hvaa211
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suck abstract from ncbi


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pmid32894750      Clin+Chem 2020 ; 66 (12): 1538-1547
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  • Association between SARS-CoV-2 Neutralizing Antibodies and Commercial Serological Assays #MMPMID32894750
  • Tang MS; Case JB; Franks CE; Chen RE; Anderson NW; Henderson JP; Diamond MS; Gronowski AM; Farnsworth CW
  • Clin Chem 2020[Dec]; 66 (12): 1538-1547 PMID32894750show ga
  • BACKGROUND: Commercially available SARS-CoV-2 serological assays based on different viral antigens have been approved for the qualitative determination of anti-SARS-CoV-2 antibodies. However, there are limited published data associating the results from commercial assays with neutralizing antibodies. METHODS: Sixty-six specimens from 48 patients with PCR-confirmed COVID-19 and a positive result by the Roche Elecsys Anti-SARS-CoV-2, Abbott SARS-CoV-2 IgG, or EUROIMMUN SARS-CoV-2 IgG assays and 5 control specimens were analyzed for the presence of neutralizing antibodies to SARS-CoV-2. Correlation, concordance, positive percent agreement (PPA), and negative percent agreement (NPA) were calculated at several cutoffs. Results were compared in patients categorized by clinical outcomes. RESULTS: The correlation between SARS-CoV-2 neutralizing titer (EC50) and the Roche, Abbott, and EUROIMMUN assays was 0.29, 0.47, and 0.46, respectively. At an EC50 of 1:32, the concordance kappa with Roche was 0.49 (95% CI; 0.23-0.75), with Abbott was 0.52 (0.28-0.77), and with EUROIMMUN was 0.61 (0.4-0.82). At the same neutralizing titer, the PPA and NPA for the Roche was 100% (94-100) and 56% (30-80); Abbott was 96% (88-99) and 69% (44-86); and EUROIMMUN was 91% (80-96) and 81% (57-93) for distinguishing neutralizing antibodies. Patients who were intubated, had cardiac injury, or acute kidney injury from COVID-19 infection had higher neutralizing titers relative to those with mild symptoms. CONCLUSIONS: COVID-19 patients generate an antibody response to multiple viral proteins such that the calibrator ratios on the Roche, Abbott, and EUROIMMUN assays are all associated with SARS-CoV-2 neutralization. Nevertheless, commercial serological assays have poor NPA for SARS-CoV-2 neutralization, making them imperfect proxies for neutralization.
  • |Aged[MESH]
  • |Antibodies, Neutralizing/*analysis/immunology[MESH]
  • |Antibodies, Viral/*analysis/immunology[MESH]
  • |COVID-19 Serological Testing/*statistics & numerical data[MESH]
  • |COVID-19/epidemiology/*immunology[MESH]
  • |Coronavirus Nucleocapsid Proteins/immunology[MESH]
  • |Correlation of Data[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunoassay/*statistics & numerical data[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Phosphoproteins/immunology[MESH]
  • |ROC Curve[MESH]
  • |SARS-CoV-2/chemistry/*immunology[MESH]
  • |Severity of Illness Index[MESH]


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