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10.1021/acs.chemrestox.0c00299 http://scihub22266oqcxt.onion/10.1021/acs.chemrestox.0c00299 32894672!9297005!32894672     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Chem+Res+Toxicol 2020 ; 33 (10): 2668-2674 Nephropedia Template TP {{tp|p=32894672|t=2020. Protective Role of Glutathione against Peroxynitrite-Mediated DNA Damage During Acute Inflammation |pdf=|usr=}}{{32894672}} gab.com Text Protective Role of Glutathione against Peroxynitrite-Mediated DNA Damage During Acute Inflammation JO: Chem Res Toxicol http://www.kidney.de/pget.php?&tw=1&pmid=32894672 #FOAvip Inflammation is an immune response to protect against various types of infections. When unchecked, acute inflammation can be life-threatening, as seen with the current coronavirus pandemic. Strong oxidants, such as peroxynitrite produced by immune cells, are major mediators of the inflammation-associated pathogenesis. Cellular thiols play important roles in mitigating inflammation-associated macromolecular damage including DNA. Herein, we have demonstrated a role of glutathione (GSH) and other thiols in neutralizing the effect of peroxynitrite-mediated DNA damage through stable GSH-DNA adduct formation. Our observation supports the use of thiol supplements as a potential therapeutic strategy against severe COVID-19 cases and a Phase II (NCT04374461) open-label clinical trial launched in early May 2020 by the Memorial Sloan Kettering Cancer Center. Twit Text FOAVip Protective Role of Glutathione against Peroxynitrite-Mediated DNA Damage During Acute Inflammation ????Chem Res Toxicol http://www.kidney.de/pget.php?&tw=1&pmid=32894672 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32894672 #FOAvip English Wikipedia <ref>{{Cite pmid|32894672}}</ref> Protective Role of Glutathione against Peroxynitrite-Mediated DNA Damage During Acute Inflammation #MMPMID32894672 Ahmed N; Chakrabarty A; Guengerich FP; Chowdhury G Chem Res Toxicol 2020[Oct]; 33 (10): 2668-2674 PMID32894672show ga Inflammation is an immune response to protect against various types of infections. When unchecked, acute inflammation can be life-threatening, as seen with the current coronavirus pandemic. Strong oxidants, such as peroxynitrite produced by immune cells, are major mediators of the inflammation-associated pathogenesis. Cellular thiols play important roles in mitigating inflammation-associated macromolecular damage including DNA. Herein, we have demonstrated a role of glutathione (GSH) and other thiols in neutralizing the effect of peroxynitrite-mediated DNA damage through stable GSH-DNA adduct formation. Our observation supports the use of thiol supplements as a potential therapeutic strategy against severe COVID-19 cases and a Phase II (NCT04374461) open-label clinical trial launched in early May 2020 by the Memorial Sloan Kettering Cancer Center. |Acute Disease[MESH] |Animals[MESH] |Betacoronavirus[MESH] |COVID-19[MESH] |Cattle[MESH] |Coronavirus Infections/drug therapy[MESH] |DNA Adducts/chemistry/*drug effects[MESH] |DNA Damage[MESH] |DNA/chemistry/*drug effects[MESH] |Glutathione/chemistry/*pharmacology[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Inflammation/*physiopathology[MESH] |Mutagens/chemistry/pharmacology[MESH] |Pandemics[MESH] |Peroxynitrous Acid/*adverse effects/chemistry[MESH] |Pneumonia, Viral/drug therapy[MESH] |SARS-CoV-2[MESH]Protective Role of Glutathione against Peroxynitrite-Mediated DNA Dama(epmc).pdf DeepDyve Pubget Overpricing