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10.3233/JPD-202163

http://scihub22266oqcxt.onion/10.3233/JPD-202163
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32894251!ä!32894251

suck abstract from ncbi


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pmid32894251      J+Parkinsons+Dis 2020 ; 10 (4): 1779-1786
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  • Feasibility, Reliability, and Value of Remote Video-Based Trial Visits in Parkinson s Disease #MMPMID32894251
  • Tarolli CG; Andrzejewski K; Zimmerman GA; Bull M; Goldenthal S; Auinger P; O'Brien M; Dorsey ER; Biglan K; Simuni T
  • J Parkinsons Dis 2020[]; 10 (4): 1779-1786 PMID32894251show ga
  • BACKGROUND: There is rising interest in remote clinical trial assessments, particularly in the setting of the COVID-19 pandemic. OBJECTIVE: To demonstrate the feasibility, reliability, and value of remote visits in a phase III clinical trial of individuals with Parkinson's disease. METHODS: We invited individuals with Parkinson's disease enrolled in a phase III clinical trial (STEADY-PD III) to enroll in a sub-study of remote video-based visits. Participants completed three remote visits over one year within four weeks of an in-person visit and completed assessments performed during the remote visit. We evaluated the ability to complete scheduled assessments remotely; agreement between remote and in-person outcome measures; and opinions of remote visits. RESULTS: We enrolled 40 participants (mean (SD) age 64.3 (10.4), 29% women), and 38 (95%) completed all remote visits. There was excellent correlation (ICC 0.81-0.87) between remote and in-person patient-reported outcomes, and moderate correlation (ICC 0.43-0.51) between remote and in-person motor assessments. On average, remote visits took around one quarter of the time of in-person visits (54 vs 190 minutes). Nearly all participants liked remote visits, and three-quarters said they would be more likely to participate in future trials if some visits could be conducted remotely. CONCLUSION: Remote visits are feasible and reliable in a phase III clinical trial of individuals with early, untreated Parkinson's disease. These visits are shorter, reduce participant burden, and enable safe conduct of research visits, which is especially important in the COVID-19 pandemic.
  • |*Coronavirus Infections[MESH]
  • |*Pandemics[MESH]
  • |*Pneumonia, Viral[MESH]
  • |*Research Design[MESH]
  • |Aged[MESH]
  • |COVID-19[MESH]
  • |Feasibility Studies[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Parkinson Disease/*therapy[MESH]
  • |Reproducibility of Results[MESH]


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