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10.7554/eLife.59566 http://scihub22266oqcxt.onion/10.7554/eLife.59566 32894223!7535934!32894223     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Elife 2020 ; 9 (ä): ä Nephropedia Template TP {{tp|p=32894223|t=2020. Extensive and diverse patterns of cell death sculpt neural networks in insects |pdf=|usr=}}{{32894223}} gab.com Text Extensive and diverse patterns of cell death sculpt neural networks in insects JO: Elife http://www.kidney.de/pget.php?&tw=1&pmid=32894223 #FOAvip Changes to the structure and function of neural networks are thought to underlie the evolutionary adaptation of animal behaviours. Among the many developmental phenomena that generate change programmed cell death (PCD) appears to play a key role. We show that cell death occurs continuously throughout insect neurogenesis and happens soon after neurons are born. Mimicking an evolutionary role for increasing cell numbers, we artificially block in the medial neuroblast lineage in Drosophila melanogaster, which results in the production of 'undead' neurons with complex arborisations and distinct neurotransmitter identities. Activation of these 'undead' neurons and recordings of neural activity in behaving animals demonstrate that they are functional. Focusing on two dipterans, which have lost flight during evolution, we reveal that reductions in populations of flight interneurons are likely caused by increased cell death during development. Our findings suggest that the evolutionary modulation of death-based patterning could generate novel network configurations. Twit Text FOAVip Extensive and diverse patterns of cell death sculpt neural networks in insects ????Elife http://www.kidney.de/pget.php?&tw=1&pmid=32894223 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32894223 #FOAvip English Wikipedia <ref>{{Cite pmid|32894223}}</ref> Extensive and diverse patterns of cell death sculpt neural networks in insects #MMPMID32894223 Pop S; Chen CL; Sproston CJ; Kondo S; Ramdya P; Williams DW Elife 2020[Sep]; 9 (ä): ä PMID32894223show ga Changes to the structure and function of neural networks are thought to underlie the evolutionary adaptation of animal behaviours. Among the many developmental phenomena that generate change programmed cell death (PCD) appears to play a key role. We show that cell death occurs continuously throughout insect neurogenesis and happens soon after neurons are born. Mimicking an evolutionary role for increasing cell numbers, we artificially block in the medial neuroblast lineage in Drosophila melanogaster, which results in the production of 'undead' neurons with complex arborisations and distinct neurotransmitter identities. Activation of these 'undead' neurons and recordings of neural activity in behaving animals demonstrate that they are functional. Focusing on two dipterans, which have lost flight during evolution, we reveal that reductions in populations of flight interneurons are likely caused by increased cell death during development. Our findings suggest that the evolutionary modulation of death-based patterning could generate novel network configurations. |*Nerve Net/cytology/physiology[MESH] |*Neurons/cytology/physiology[MESH] |Animals[MESH] |Apoptosis/*physiology[MESH] |Biological Evolution[MESH] |Drosophila Proteins/metabolism[MESH] |Drosophila melanogaster[MESH] |Flight, Animal/physiology[MESH]Extensive and diverse patterns of cell death sculpt neural networks in(epmc).pdf DeepDyve Pubget Overpricing