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10.1016/j.jiac.2020.08.001

http://scihub22266oqcxt.onion/10.1016/j.jiac.2020.08.001
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32893123!7409929!32893123
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suck abstract from ncbi


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pmid32893123      J+Infect+Chemother 2020 ; 26 (12): 1319-1323
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  • Clinical improvement in a patient with severe coronavirus disease 2019 after administration of hydroxychloroquine and continuous hemodiafiltlation with nafamostat mesylate #MMPMID32893123
  • Iwasaka S; Shono Y; Tokuda K; Nakashima K; Yamamoto Y; Maki J; Nagasaki Y; Shimono N; Akahoshi T; Taguchi T
  • J Infect Chemother 2020[Dec]; 26 (12): 1319-1323 PMID32893123show ga
  • The number of people infected with severe acute respiratory syndrome coronavirus 2 is increasing globally, and some patients have a fatal clinical course. In light of this situation, the World Health Organization (WHO) declared coronavirus disease 2019 (COVID-19) a pandemic on March 11, 2020. While clinical studies and basic research on a treatment for COVID-19 are ongoing around the world, no treatment has yet been proven to be effective. Several clinical studies have demonstrated the efficacy of chloroquine phosphate and nafamostat mesylate with COVID-19. Here, we report the case of a Japanese patient with COVID-19 with severe respiratory failure who improved following the administration of hydroxychloroquine and continuous hemodiafiltlation with nafamostat mesylate. Hence, hydroxychloroquine with nafamostat mesylate might be a treatment option for severe COVID-19.
  • |Aged[MESH]
  • |Anti-Inflammatory Agents, Non-Steroidal/administration & dosage[MESH]
  • |Antiviral Agents/administration & dosage[MESH]
  • |Benzamidines[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |Coronavirus Infections/complications/*drug therapy/therapy[MESH]
  • |Drug Combinations[MESH]
  • |Guanidines/*administration & dosage[MESH]
  • |Hemodiafiltration/*methods[MESH]
  • |Humans[MESH]
  • |Hydroxychloroquine/*administration & dosage[MESH]
  • |Japan[MESH]
  • |Lopinavir/administration & dosage[MESH]
  • |Male[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/complications/*drug therapy/therapy[MESH]
  • |Respiratory Insufficiency/complications[MESH]
  • |Ritonavir/administration & dosage[MESH]
  • |SARS-CoV-2[MESH]


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