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10.1111/nyas.14472 http://scihub22266oqcxt.onion/10.1111/nyas.14472 32892378!7933981!32892378     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Ann+N+Y+Acad+Sci 2020 ; 1480 (1): 73-103 Nephropedia Template TP {{tp|p=32892378|t=2020. Transient receptor potential channels in pulmonary chemical injuries and as countermeasure targets |pdf=|usr=}}{{32892378}} gab.com Text Transient receptor potential channels in pulmonary chemical injuries and as countermeasure targets JO: Ann N Y Acad Sci http://www.kidney.de/pget.php?&tw=1&pmid=32892378 #FOAvip The lung is highly sensitive to chemical injuries caused by exposure to threat agents in industrial or transportation accidents, occupational exposures, or deliberate use as weapons of mass destruction (WMD). There are no antidotes for the majority of the chemical threat agents and toxic inhalation hazards despite their use as WMDs for more than a century. Among several putative targets, evidence for transient receptor potential (TRP) ion channels as mediators of injury by various inhalational chemical threat agents is emerging. TRP channels are expressed in the respiratory system and are essential for homeostasis. Among TRP channels, the body of literature supporting essential roles for TRPA1, TRPV1, and TRPV4 in pulmonary chemical injuries is abundant. TRP channels mediate their function through sensory neuronal and nonneuronal pathways. TRP channels play a crucial role in complex pulmonary pathophysiologic events including, but not limited to, increased intracellular calcium levels, signal transduction, recruitment of proinflammatory cells, neurogenic inflammatory pathways, cough reflex, hampered mucus clearance, disruption of the integrity of the epithelia, pulmonary edema, and fibrosis. In this review, we summarize the role of TRP channels in chemical threat agents-induced pulmonary injuries and how these channels may serve as medical countermeasure targets for broader indications. Twit Text FOAVip Transient receptor potential channels in pulmonary chemical injuries and as countermeasure targets ????Ann N Y Acad Sci http://www.kidney.de/pget.php?&tw=1&pmid=32892378 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32892378 #FOAvip English Wikipedia <ref>{{Cite pmid|32892378}}</ref> Transient receptor potential channels in pulmonary chemical injuries and as countermeasure targets #MMPMID32892378 Achanta S; Jordt SE Ann N Y Acad Sci 2020[Nov]; 1480 (1): 73-103 PMID32892378show ga The lung is highly sensitive to chemical injuries caused by exposure to threat agents in industrial or transportation accidents, occupational exposures, or deliberate use as weapons of mass destruction (WMD). There are no antidotes for the majority of the chemical threat agents and toxic inhalation hazards despite their use as WMDs for more than a century. Among several putative targets, evidence for transient receptor potential (TRP) ion channels as mediators of injury by various inhalational chemical threat agents is emerging. TRP channels are expressed in the respiratory system and are essential for homeostasis. Among TRP channels, the body of literature supporting essential roles for TRPA1, TRPV1, and TRPV4 in pulmonary chemical injuries is abundant. TRP channels mediate their function through sensory neuronal and nonneuronal pathways. TRP channels play a crucial role in complex pulmonary pathophysiologic events including, but not limited to, increased intracellular calcium levels, signal transduction, recruitment of proinflammatory cells, neurogenic inflammatory pathways, cough reflex, hampered mucus clearance, disruption of the integrity of the epithelia, pulmonary edema, and fibrosis. In this review, we summarize the role of TRP channels in chemical threat agents-induced pulmonary injuries and how these channels may serve as medical countermeasure targets for broader indications. |*Lung Injury/chemically induced/metabolism/physiopathology/therapy[MESH] |*Lung/metabolism/pathology/physiopathology[MESH] |Animals[MESH] |Calcium Signaling/drug effects[MESH] |Calcium/metabolism[MESH] |Chemical Warfare Agents/*poisoning[MESH] |Humans[MESH] |TRPA1 Cation Channel/*metabolism[MESH]Transient receptor potential channels in pulmonary chemical injuries a(epmc).pdf DeepDyve Pubget Overpricing