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10.1016/j.prrv.2020.08.001

http://scihub22266oqcxt.onion/10.1016/j.prrv.2020.08.001
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suck abstract from ncbi


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pmid32891582      Paediatr+Respir+Rev 2021 ; 38 (ä): 51-57
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  • Multi-system inflammatory syndrome in children & adolescents (MIS-C): A systematic review of clinical features and presentation #MMPMID32891582
  • Radia T; Williams N; Agrawal P; Harman K; Weale J; Cook J; Gupta A
  • Paediatr Respir Rev 2021[Jun]; 38 (ä): 51-57 PMID32891582show ga
  • Multisystem Inflammatory Syndrome in Children (MIS-C) is a new phenomenon reported worldwide with temporal association with Covid-19. The objective of this paper is to evaluate reported cases in children and adolescents. From 1726 papers, 35 documented papers related to MIS-C cases identified 783 individual cases of MIS-C between March-June 2020; with 55% being male (n?=?435) and a median age of 8.6?years (IQR, 7-10?years; range 3?months-20?years). Patients with MIS-C were noted to have a high frequency of gastrointestinal symptoms (71%) including abdominal pain (34%) and diarrhea (27%). Cough and respiratory distress were reported in 4.5% and 9.6% cases respectively. Blood parameters showed neutrophilia in 345/418 (83%) of cases and a high CRP in 587/626 (94%). 362/619 (59%) cases were SARS-CoV-2 infection positive (serology or PCR) however only 41% demonstrated pulmonary changes on chest imaging. Severity of illness was high with 68% cases requiring intensive care admission; 63% requiring inotropic support; 244/783 (28%) cases needing some form of respiratory support (138 mechanically ventilated), and 31 required extra-corporeal membrane oxygenation. Treatment strategies included intravenous immunoglobulin (63%) and intravenous steroids (44%). 29 cases received Infliximab, 47 received IL1 (interleukin) receptor antagonist, and 47 received IL6-receptor antagonist. 12/783 (1.5%) children died. In summary, a higher incidence of gastrointestinal symptoms were noted in MIS-C. In contrast to acute Covid-19 infection in children, MIS-C appears to be a condition of higher severity with 68% of cases having required critical care support.
  • |Adolescent[MESH]
  • |COVID-19/complications/*diagnosis/therapy[MESH]
  • |Child[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]


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