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10.1016/j.biopha.2020.110622

http://scihub22266oqcxt.onion/10.1016/j.biopha.2020.110622
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suck abstract from ncbi


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pmid32890967      Biomed+Pharmacother 2020 ; 131 (ä): 110622
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  • Propolis and its potential against SARS-CoV-2 infection mechanisms and COVID-19 disease: Running title: Propolis against SARS-CoV-2 infection and COVID-19 #MMPMID32890967
  • Berretta AA; Silveira MAD; Condor Capcha JM; De Jong D
  • Biomed Pharmacother 2020[Nov]; 131 (ä): 110622 PMID32890967show ga
  • Propolis, a resinous material produced by honey bees from plant exudates, has long been used in traditional herbal medicine and is widely consumed as a health aid and immune system booster. The COVID-19 pandemic has renewed interest in propolis products worldwide; fortunately, various aspects of the SARS-CoV-2 infection mechanism are potential targets for propolis compounds. SARS-CoV-2 entry into host cells is characterized by viral spike protein interaction with cellular angiotensin-converting enzyme 2 (ACE2) and serine protease TMPRSS2. This mechanism involves PAK1 overexpression, which is a kinase that mediates coronavirus-induced lung inflammation, fibrosis, and immune system suppression. Propolis components have inhibitory effects on the ACE2, TMPRSS2 and PAK1 signaling pathways; in addition, antiviral activity has been proven in vitro and in vivo. In pre-clinical studies, propolis promoted immunoregulation of pro-inflammatory cytokines, including reduction in IL-6, IL-1 beta and TNF-alpha. This immunoregulation involves monocytes and macrophages, as well as Jak2/STAT3, NF-kB, and inflammasome pathways, reducing the risk of cytokine storm syndrome, a major mortality factor in advanced COVID-19 disease. Propolis has also shown promise as an aid in the treatment of various of the comorbidities that are particularly dangerous in COVID-19 patients, including respiratory diseases, hypertension, diabetes, and cancer. Standardized propolis products with consistent bioactive properties are now available. Given the current emergency caused by the COVID-19 pandemic and limited therapeutic options, propolis is presented as a promising and relevant therapeutic option that is safe, easy to administrate orally and is readily available as a natural supplement and functional food.
  • |Animals[MESH]
  • |Antiviral Agents/administration & dosage/*pharmacology[MESH]
  • |Betacoronavirus/drug effects/isolation & purification[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |Coronavirus Infections/complications/*drug therapy/virology[MESH]
  • |Dietary Supplements[MESH]
  • |Functional Food[MESH]
  • |Humans[MESH]
  • |Macrophages/drug effects/immunology[MESH]
  • |Monocytes/drug effects/immunology[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/complications/*drug therapy/virology[MESH]
  • |Propolis/administration & dosage/*pharmacology[MESH]


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