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10.1016/j.meegid.2020.104525 http://scihub22266oqcxt.onion/10.1016/j.meegid.2020.104525 32890763!7467077!32890763     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Infect+Genet+Evol 2020 ; 85 (ä): 104525 Nephropedia Template TP {{tp|p=32890763|t=2020. Evolutionary dynamics of the SARS-CoV-2 ORF8 accessory gene |pdf=|usr=}}{{32890763}} gab.com Text Evolutionary dynamics of the SARS-CoV-2 ORF8 accessory gene JO: Infect Genet Evol http://www.kidney.de/pget.php?&tw=1&pmid=32890763 #FOAvip The new SARS-CoV-2 poses a significant threat to human health but many aspects of its basic biology remain unknown. Its genome encodes accessory genes that differ significantly within coronaviruses and contribute to the virus pathogenicity. Among accessory genes, open reading frame 8 (ORF8) stands out by being highly variable and showing structural changes suspected to be related with the virus ability to spread. However, the function of ORF8 remains to be elucidated, making it less studied than other SARS-CoV-2 genes. Here I show that ORF8 is poorly conserved among related coronaviruses. The ORF8 phylogeny built using 11,113 SARS-CoV-2 sequences revealed traces of a typical expanding population with a small number of highly frequent lineages. Interestingly, I detected several nonsense mutations and three main deletions in the ORF8 gene that either remove or significantly change the ORF8 protein. These findings suggest that SARS-CoV-2 can persist without a functional ORF8 protein. Deletion breakpoints were found located in predicted hairpins suggesting a possible involvement of these elements in the rearrangement process. Although the function of ORF8 remains to be elucidated, its structural plasticity and high diversity suggest an important role in SARS-CoV-2 pathogenicity. Twit Text FOAVip Evolutionary dynamics of the SARS-CoV-2 ORF8 accessory gene ????Infect Genet Evol http://www.kidney.de/pget.php?&tw=1&pmid=32890763 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32890763 #FOAvip English Wikipedia <ref>{{Cite pmid|32890763}}</ref> Evolutionary dynamics of the SARS-CoV-2 ORF8 accessory gene #MMPMID32890763 Pereira F Infect Genet Evol 2020[Nov]; 85 (ä): 104525 PMID32890763show ga The new SARS-CoV-2 poses a significant threat to human health but many aspects of its basic biology remain unknown. Its genome encodes accessory genes that differ significantly within coronaviruses and contribute to the virus pathogenicity. Among accessory genes, open reading frame 8 (ORF8) stands out by being highly variable and showing structural changes suspected to be related with the virus ability to spread. However, the function of ORF8 remains to be elucidated, making it less studied than other SARS-CoV-2 genes. Here I show that ORF8 is poorly conserved among related coronaviruses. The ORF8 phylogeny built using 11,113 SARS-CoV-2 sequences revealed traces of a typical expanding population with a small number of highly frequent lineages. Interestingly, I detected several nonsense mutations and three main deletions in the ORF8 gene that either remove or significantly change the ORF8 protein. These findings suggest that SARS-CoV-2 can persist without a functional ORF8 protein. Deletion breakpoints were found located in predicted hairpins suggesting a possible involvement of these elements in the rearrangement process. Although the function of ORF8 remains to be elucidated, its structural plasticity and high diversity suggest an important role in SARS-CoV-2 pathogenicity. |Codon, Nonsense[MESH] |Evolution, Molecular[MESH] |Models, Molecular[MESH] |Molecular Conformation[MESH] |Phylogeny[MESH] |SARS-CoV-2/chemistry/*genetics[MESH] |Sequence Analysis, RNA/*methods[MESH] |Sequence Deletion[MESH]Evolutionary dynamics of the SARS-CoV-2 ORF8 accessory gene (epmc).pdf DeepDyve Pubget Overpricing