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10.1097/QAD.0000000000002639

http://scihub22266oqcxt.onion/10.1097/QAD.0000000000002639
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32889852!7493781!32889852
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suck abstract from ncbi


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pmid32889852      AIDS 2020 ; 34 (12): 1765-1770
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  • Coronavirus disease 2019 attack rate in HIV-infected patients and in preexposure prophylaxis users #MMPMID32889852
  • Charre C; Icard V; Pradat P; Brochier C; Lina B; Chidiac C; Cotte L
  • AIDS 2020[Oct]; 34 (12): 1765-1770 PMID32889852show ga
  • OBJECTIVE: A new coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) emerged in China during late 2019 and resulted in the coronavirus disease 2019 (COVID-19) pandemic which peaked in France in March-April 2020. Immunodeficiency, precariousness and promiscuity could increase the risk of COVID-19 in HIV-infected patients and in preexposure prophylaxis (PrEP) users. No epidemiological data are available in these two populations. We report COVID-19 attack rate in HIV-infected patients and in PrEP users in the Rhone department, France, and compared it with the general population. DESIGN: Retrospective analysis of a laboratory database. METHODS: COVID-19 testing strategy in France was centered on symptomatic infections, hospitalized patients and symptomatic healthcare workers while most asymptomatic cases were not confirmed. SARS-CoV-2 positivity rate on PCR assays and COVID-19 attack rate were determined in HIV-infected patients and in PrEP users. COVID-19 attack rate in the general population was estimated from health authorities' database and demographic data. A corrected attack rate taking into account the laboratory representativeness was calculated. RESULTS: From March to April 2020, 24 860 samples from 19 113 patients (HIV-infected 77, PrEP users 27, others 19 009) were assessed for SARS-CoV-2 PCR assay. The positivity rate appeared similar in HIV-infected patients (15.6%), in PrEP users (14.8%) and in other patients (19.1%). The crude/corrected COVID-19 attack rate appeared similar in HIV-infected patients (0.31/0.38%) and in PrEP users (0.38/0.42%), and of the same order as the estimated attack rate in the general population (0.24%). CONCLUSION: The risk of symptomatic COVID-19 in France appeared similar in HIV-infected patients and in PrEP users compared with the general population.
  • |*Pre-Exposure Prophylaxis[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Testing[MESH]
  • |Clinical Laboratory Techniques[MESH]
  • |Coronavirus Infections/diagnosis/*epidemiology[MESH]
  • |Databases, Factual[MESH]
  • |Female[MESH]
  • |France/epidemiology[MESH]
  • |HIV Infections/*complications/prevention & control[MESH]
  • |Humans[MESH]
  • |Incidence[MESH]
  • |Logistic Models[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Multivariate Analysis[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*epidemiology[MESH]
  • |Retrospective Studies[MESH]
  • |Risk Factors[MESH]


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