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10.1016/j.humimm.2020.08.001 http://scihub22266oqcxt.onion/10.1016/j.humimm.2020.08.001 32888767!7425717!32888767     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Hum+Immunol 2020 ; 81 (10-11): 588-595 Nephropedia Template TP {{tp|p=32888767|t=2020. Conserved HLA binding peptides from five non-structural proteins of SARS-CoV-2-An in silico glance |pdf=|usr=}}{{32888767}} gab.com Text Conserved HLA binding peptides from five non-structural proteins of SARS-CoV-2-An in silico glance JO: Hum Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32888767 #FOAvip Coronavirus Disease 2019 (COVID-19) is a dangerous global threat that has no clinically approved treatment yet. Bioinformatics represent an outstanding approach to reveal key immunogenic regions in viral proteins. Here, five severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) non-structural proteins (NSPs) (NSP7, NSP8, NSP9, NSP12, and NSP13) were screened to identify potential human leukocyte antigen (HLA) binding peptides. These peptides showed robust viral antigenicity, immunogenicity, and a marked interaction with HLA alleles. Interestingly, several peptides showed affinity by HLA class I (HLA-I) alleles that commonly activates to natural killer (NK) cells. Notably, HLA biding peptides are conserved among SARS-CoV-2, severe acute respiratory syndrome coronavirus (SARS-CoV), and Middle Eastern respiratory syndrome coronavirus (MERS-CoV). Interestingly, HLA-I and HLA class II (HLA-II) binding peptides induced humoral and cell-mediated responses after in silico vaccination. These results may open further in vitro and in vivo investigations to develop novel therapeutic strategies against coronaviral infections. Twit Text FOAVip Conserved HLA binding peptides from five non-structural proteins of SARS-CoV-2-An in silico glance ????Hum Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32888767 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32888767 #FOAvip English Wikipedia <ref>{{Cite pmid|32888767}}</ref> Conserved HLA binding peptides from five non-structural proteins of SARS-CoV-2-An in silico glance #MMPMID32888767 Marchan J Hum Immunol 2020[Oct]; 81 (10-11): 588-595 PMID32888767show ga Coronavirus Disease 2019 (COVID-19) is a dangerous global threat that has no clinically approved treatment yet. Bioinformatics represent an outstanding approach to reveal key immunogenic regions in viral proteins. Here, five severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) non-structural proteins (NSPs) (NSP7, NSP8, NSP9, NSP12, and NSP13) were screened to identify potential human leukocyte antigen (HLA) binding peptides. These peptides showed robust viral antigenicity, immunogenicity, and a marked interaction with HLA alleles. Interestingly, several peptides showed affinity by HLA class I (HLA-I) alleles that commonly activates to natural killer (NK) cells. Notably, HLA biding peptides are conserved among SARS-CoV-2, severe acute respiratory syndrome coronavirus (SARS-CoV), and Middle Eastern respiratory syndrome coronavirus (MERS-CoV). Interestingly, HLA-I and HLA class II (HLA-II) binding peptides induced humoral and cell-mediated responses after in silico vaccination. These results may open further in vitro and in vivo investigations to develop novel therapeutic strategies against coronaviral infections. |Amino Acid Sequence[MESH] |Betacoronavirus/genetics/*immunology[MESH] |COVID-19[MESH] |COVID-19 Vaccines[MESH] |Conserved Sequence/*immunology[MESH] |Coronavirus Infections/blood/*immunology/prevention & control/therapy/virology[MESH] |HLA Antigens/*immunology/metabolism[MESH] |Humans[MESH] |Immunity, Cellular/immunology[MESH] |Immunity, Humoral/immunology[MESH] |Killer Cells, Natural/immunology/metabolism[MESH] |Middle East Respiratory Syndrome Coronavirus/genetics/immunology[MESH] |Molecular Docking Simulation[MESH] |Pandemics[MESH] |Pneumonia, Viral/blood/*immunology/therapy/virology[MESH] |SARS-CoV-2[MESH] |Severe acute respiratory syndrome-related coronavirus/genetics/immunology[MESH] |Vaccines, Subunit/immunology[MESH] |Viral Nonstructural Proteins/genetics/*immunology/metabolism[MESH]Conserved HLA binding peptides from five non-structural proteins of SA(epmc).pdf DeepDyve Pubget Overpricing