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10.1016/j.pathol.2020.08.001 http://scihub22266oqcxt.onion/10.1016/j.pathol.2020.08.001 32888706!7437539!32888706     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Pathology 2020 ; 52 (7): 801-808 Nephropedia Template TP {{tp|p=32888706|t=2020. SARS-CoV-2 in children: spectrum of disease, transmission and immunopathological underpinnings |pdf=|usr=}}{{32888706}} gab.com Text SARS-CoV-2 in children: spectrum of disease, transmission and immunopathological underpinnings JO: Pathology http://www.kidney.de/pget.php?&tw=1&pmid=32888706 #FOAvip As the SARS-CoV-2 pandemic unfolds across the globe, consistent themes are emerging with regard to aspects of SARS-CoV-2 infection and its associated disease entities in children. Overall, children appear to be less frequently infected by, and affected by, SARS-CoV-2 virus and the clinical disease COVID-19. Large epidemiological studies have revealed children represent less than 2% of the total confirmed COVID-19 cases, of whom the majority experience minimal or mild disease that do not require hospitalisation. Children do not appear to be major drivers of SARS-CoV-2 transmission, with minimal secondary virus transmission demonstrated within families, schools and community settings. There are several postulated theories regarding the relatively low SARS-CoV-2 morbidity and mortality seen in children, which largely relate to differences in immune responses compared to adults, as well as differences in angiotensin converting enzyme 2 distribution that potentially limits viral entry and subsequent inflammation, hypoxia and tissue injury. The recent emergence of a multisystem inflammatory syndrome bearing temporal and serological plausibility for an immune-mediated SARS-CoV-2-related disease entity is currently under investigation. This article summarises the current available data regarding SARS-CoV-2 and the paediatric population, including the spectrum of disease in children, the role of children in virus transmission, and host-virus factors that underpin the unique aspects of SARS-CoV-2 pathogenicity in children. Twit Text FOAVip SARS-CoV-2 in children: spectrum of disease, transmission and immunopathological underpinnings ????Pathology http://www.kidney.de/pget.php?&tw=1&pmid=32888706 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32888706 #FOAvip English Wikipedia <ref>{{Cite pmid|32888706}}</ref> SARS-CoV-2 in children: spectrum of disease, transmission and immunopathological underpinnings #MMPMID32888706 Williams PCM; Howard-Jones AR; Hsu P; Palasanthiran P; Gray PE; McMullan BJ; Britton PN; Bartlett AW Pathology 2020[Dec]; 52 (7): 801-808 PMID32888706show ga As the SARS-CoV-2 pandemic unfolds across the globe, consistent themes are emerging with regard to aspects of SARS-CoV-2 infection and its associated disease entities in children. Overall, children appear to be less frequently infected by, and affected by, SARS-CoV-2 virus and the clinical disease COVID-19. Large epidemiological studies have revealed children represent less than 2% of the total confirmed COVID-19 cases, of whom the majority experience minimal or mild disease that do not require hospitalisation. Children do not appear to be major drivers of SARS-CoV-2 transmission, with minimal secondary virus transmission demonstrated within families, schools and community settings. There are several postulated theories regarding the relatively low SARS-CoV-2 morbidity and mortality seen in children, which largely relate to differences in immune responses compared to adults, as well as differences in angiotensin converting enzyme 2 distribution that potentially limits viral entry and subsequent inflammation, hypoxia and tissue injury. The recent emergence of a multisystem inflammatory syndrome bearing temporal and serological plausibility for an immune-mediated SARS-CoV-2-related disease entity is currently under investigation. This article summarises the current available data regarding SARS-CoV-2 and the paediatric population, including the spectrum of disease in children, the role of children in virus transmission, and host-virus factors that underpin the unique aspects of SARS-CoV-2 pathogenicity in children. |COVID-19/immunology/*transmission/virology[MESH] |Child[MESH] |Child, Preschool[MESH] |Female[MESH] |Host-Pathogen Interactions/*physiology[MESH] |Humans[MESH] |Infant[MESH] |Male[MESH]SARS-CoV-2 in children: spectrum of disease, transmission and immunopa(epmc).pdf DeepDyve Pubget Overpricing