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10.1038/s41590-020-0782-6 http://scihub22266oqcxt.onion/10.1038/s41590-020-0782-6 32887977!7611020!32887977     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Immunol 2020 ; 21 (11): 1336-1345 Nephropedia Template TP {{tp|p=32887977|t=2020. Broad and strong memory CD4(+) and CD8(+) T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19 |pdf=|usr=}}{{32887977}} gab.com Text Broad and strong memory CD4(+) and CD8(+) T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19 JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32887977 #FOAvip The development of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines and therapeutics will depend on understanding viral immunity. We studied T cell memory in 42 patients following recovery from COVID-19 (28 with mild disease and 14 with severe disease) and 16 unexposed donors, using interferon-gamma-based assays with peptides spanning SARS-CoV-2 except ORF1. The breadth and magnitude of T cell responses were significantly higher in severe as compared with mild cases. Total and spike-specific T cell responses correlated with spike-specific antibody responses. We identified 41 peptides containing CD4(+) and/or CD8(+) epitopes, including six immunodominant regions. Six optimized CD8(+) epitopes were defined, with peptide-MHC pentamer-positive cells displaying the central and effector memory phenotype. In mild cases, higher proportions of SARS-CoV-2-specific CD8(+) T cells were observed. The identification of T cell responses associated with milder disease will support an understanding of protective immunity and highlights the potential of including non-spike proteins within future COVID-19 vaccine design. Twit Text FOAVip Broad and strong memory CD4(+) and CD8(+) T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19 ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32887977 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32887977 #FOAvip English Wikipedia <ref>{{Cite pmid|32887977}}</ref> Broad and strong memory CD4(+) and CD8(+) T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19 #MMPMID32887977 Peng Y; Mentzer AJ; Liu G; Yao X; Yin Z; Dong D; Dejnirattisai W; Rostron T; Supasa P; Liu C; Lopez-Camacho C; Slon-Campos J; Zhao Y; Stuart DI; Paesen GC; Grimes JM; Antson AA; Bayfield OW; Hawkins DEDP; Ker DS; Wang B; Turtle L; Subramaniam K; Thomson P; Zhang P; Dold C; Ratcliff J; Simmonds P; de Silva T; Sopp P; Wellington D; Rajapaksa U; Chen YL; Salio M; Napolitani G; Paes W; Borrow P; Kessler BM; Fry JW; Schwabe NF; Semple MG; Baillie JK; Moore SC; Openshaw PJM; Ansari MA; Dunachie S; Barnes E; Frater J; Kerr G; Goulder P; Lockett T; Levin R; Zhang Y; Jing R; Ho LP; Cornall RJ; Conlon CP; Klenerman P; Screaton GR; Mongkolsapaya J; McMichael A; Knight JC; Ogg G; Dong T Nat Immunol 2020[Nov]; 21 (11): 1336-1345 PMID32887977show ga The development of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines and therapeutics will depend on understanding viral immunity. We studied T cell memory in 42 patients following recovery from COVID-19 (28 with mild disease and 14 with severe disease) and 16 unexposed donors, using interferon-gamma-based assays with peptides spanning SARS-CoV-2 except ORF1. The breadth and magnitude of T cell responses were significantly higher in severe as compared with mild cases. Total and spike-specific T cell responses correlated with spike-specific antibody responses. We identified 41 peptides containing CD4(+) and/or CD8(+) epitopes, including six immunodominant regions. Six optimized CD8(+) epitopes were defined, with peptide-MHC pentamer-positive cells displaying the central and effector memory phenotype. In mild cases, higher proportions of SARS-CoV-2-specific CD8(+) T cells were observed. The identification of T cell responses associated with milder disease will support an understanding of protective immunity and highlights the potential of including non-spike proteins within future COVID-19 vaccine design. |Antigens, Viral/*immunology[MESH] |Betacoronavirus/*immunology[MESH] |CD4-Positive T-Lymphocytes/*immunology[MESH] |CD8-Positive T-Lymphocytes/*immunology[MESH] |COVID-19[MESH] |COVID-19 Vaccines[MESH] |Coronavirus Infections/immunology/pathology/prevention & control[MESH] |Epitopes, T-Lymphocyte/immunology[MESH] |Humans[MESH] |Immunodominant Epitopes/immunology[MESH] |Immunologic Memory/*immunology[MESH] |Pandemics[MESH] |Pneumonia, Viral/immunology/pathology[MESH] |SARS-CoV-2[MESH] |Spike Glycoprotein, Coronavirus/immunology[MESH] |United Kingdom[MESH]Broad and strong memory CD4(+) and CD8(+) T cells induced by SARS-CoV-(epmc).pdf DeepDyve Pubget Overpricing